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(Reference retrieved automatically from SciELO through information on FAPESP grant and its corresponding number as mentioned in the publication by the authors.)

Sending out an SOS - the bacterial DNA damage response

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Author(s):
Marco A. Lima-Noronha [1] ; Douglas L. H. Fonseca [2] ; Renatta S. Oliveira [3] ; Rúbia R. Freitas [4] ; Jung H. Park [5] ; Rodrigo S. Galhardo [6]
Total Authors: 6
Affiliation:
[1] Universidade de São Paulo. Instituro de Ciências Biomédicas. Departamento de Microbiologia - Brasil
[2] Universidade de São Paulo. Instituro de Ciências Biomédicas. Departamento de Microbiologia - Brasil
[3] Universidade de São Paulo. Instituro de Ciências Biomédicas. Departamento de Microbiologia - Brasil
[4] Universidade de São Paulo. Instituro de Ciências Biomédicas. Departamento de Microbiologia - Brasil
[5] Universidade de São Paulo. Instituro de Ciências Biomédicas. Departamento de Microbiologia - Brasil
[6] Universidade de São Paulo. Instituro de Ciências Biomédicas. Departamento de Microbiologia - Brasil
Total Affiliations: 6
Document type: Journal article
Source: GENETICS AND MOLECULAR BIOLOGY; v. 45, n. 3 2022-10-10.
Abstract

Abstract The term “SOS response” was first coined by Radman in 1974, in an intellectual effort to put together the data suggestive of a concerted gene expression program in cells undergoing DNA damage. A large amount of information about this cellular response has been collected over the following decades. In this review, we will focus on a few of the relevant aspects about the SOS response: its mechanism of control and the stressors which activate it, the diversity of regulated genes in different species, its role in mutagenesis and evolution including the development of antimicrobial resistance, and its relationship with mobile genetic elements. (AU)

FAPESP's process: 19/19435-3 - The role of DNA damage and mitochondrial function in vascular, immune and neurological ageing (DNA MoVINg)
Grantee:Carlos Frederico Martins Menck
Support Opportunities: Research Projects - Thematic Grants
FAPESP's process: 20/00535-5 - Influence of integrative and conjugative elements (ices) from the SXT/R391 family on physiological and pathogenic aspects of Proteus mirabilis
Grantee:Douglas Lyra de Holanda Fonseca
Support Opportunities: Scholarships in Brazil - Master
FAPESP's process: 20/12744-8 - Genomic and genetic analysis of SOS response induction in Pseudomonas aeruginosa
Grantee:Renatta Santos de Oliveira
Support Opportunities: Scholarships in Brazil - Doctorate (Direct)
FAPESP's process: 21/15170-5 - Conjugative and integrative elements of the SXT/R391 family in Proteus mirabilis
Grantee:Rodrigo da Silva Galhardo
Support Opportunities: Regular Research Grants