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(Reference retrieved automatically from SciELO through information on FAPESP grant and its corresponding number as mentioned in the publication by the authors.)

Genetic, Cellular and Molecular Aspects involved in Apical Periodontitis

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Author(s):
Igor Bassi Ferreira Petean [1] ; Alice Corrêa Silva-Sousa [2] ; Tamara Justiniano Cronenbold [3] ; Jardel Francisco Mazzi-Chaves [4] ; Lea Assed Bezerra da Silva [5] ; Raquel Assed Bezerra Segato [6] ; Guilherme Assed Piedade de Castro [7] ; Erika Calvano Kuchler ; Francisco Wanderley Garcia Paula-Silva [9] ; Manoel Damião Sousa-Neto [10]
Total Authors: 10
Affiliation:
[1] University of São Paulo. School of Dentistry of Ribeirão Preto. Department of Restorative Dentistry - Brasil
[2] University of São Paulo. School of Dentistry of Ribeirão Preto. Department of Restorative Dentistry - Brasil
[3] University of São Paulo. School of Dentistry of Ribeirão Preto. Department of Restorative Dentistry - Brasil
[4] University of São Paulo. School of Dentistry of Ribeirão Preto. Department of Restorative Dentistry - Brasil
[5] University of São Paulo. School of Dentistry of Ribeirão Preto. Department of Pediatric Dentistry - Brasil
[6] University of São Paulo. School of Dentistry of Ribeirão Preto. Department of Pediatric Dentistry - Brasil
[7] University of São Paulo. School of Dentistry of Ribeirão Preto. Department of Restorative Dentistry - Brasil
[9] University of São Paulo. School of Dentistry of Ribeirão Preto. Department of Pediatric Dentistry - Brasil
[10] University of São Paulo. School of Dentistry of Ribeirão Preto. Department of Restorative Dentistry - Brasil
Total Affiliations: 10
Document type: Journal article
Source: Brazilian Dental Journal; v. 33, n. 4, p. 1-11, 2022-08-26.
Abstract

Abstract The development, establishment and repair of apical periodontitis (AP) is dependent of several factors, which include host susceptibility, microbial infection, immune response, quality of root canal treatment and organism's ability to repair. The understanding of genetic contributions to the risk of developing AP and presenting persistent AP has been extensively explored in modern Endodontics. Thus, this article aims to provide a review of the literature regarding the biochemical mediators involved in immune response signaling, osteoclastogenesis and bone neoformation, as the genetic components involved in the development and repair of AP. A narrative review of the literature was performed through a PUBMED/MEDLINE search and a hand search of the major AP textbooks. The knowledge regarding the cells, receptors and molecules involved in the host's immune-inflammatory response during the progression of AP added to the knowledge of bone biology allows the identification of factors inherent to the host that can interfere both in the progression and in the repair of these lesions. The main outcomes of studies evaluated in the review that investigated the correlation between genetic polymorphisms and AP in the last five years, demonstrate that genetic factors of the individual are involved in the success of root canal treatment. The discussion of this review gives subsides that may help to glimpse the development of new therapies based on the identification of therapeutic targets and the development of materials and techniques aimed at acting at the molecular level for clinical, radiographic and histological success of root canal treatment. (AU)

FAPESP's process: 10/17611-4 - Mechanisms involved in the regulation of 5-lipoxygenase pathway in experimentally-induced apical periodontitis
Grantee:Francisco Wanderley Garcia de Paula e Silva
Support Opportunities: Research Grants - Young Investigators Grants
FAPESP's process: 13/09595-7 - The role of selective and non-selective inhibitors enzyme cyclooxygenase-2 and 5-lipoxygenase enzyme in osteoclastogenesis after the development of experimental periapical
Grantee:Igor Bassi Ferreira Petean
Support Opportunities: Scholarships in Brazil - Scientific Initiation
FAPESP's process: 15/06866-5 - Evaluation of the role of estrogen in dentofacial development
Grantee:Erika Calvano Kuchler
Support Opportunities: Research Grants - Young Investigators Grants