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Paper-based Wearable Electrochemical Sensors: a New Generation of Analytical Devices

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Deroco, Patricia Batista ; Wachholz Junior, Dagwin ; Kubota, Lauro Tatsuo
Total Authors: 3
Document type: Journal article
Source: Electroanalysis; v. N/A, p. 12-pg., 2022-06-28.

Over the past few years, the emergence of electrochemical wearable sensors has attracted considerable attention because of their promising application in point-of-care testing due to some features such as high sensitivity, simplicity, miniaturization, and low fabrication cost. Recent developments in new fabrication approaches and innovative substrates have resulted in sensors able to real-time and on-body measurements. Wearable electrochemical sensors have also been combined with paper-based substrates and directly used on human skin for different applications for non-invasive analyses. Furthermore, wearable electrochemical sensors enable monitoring analytes in different biofluids without complex procedures, such as pre-treatment or sample manipulation. The coupling of IoT to various wearable sensors has also attracted attention due to real-time data collection and handling in remote and resource-limited conditions. This mini-review presents the significant advances in developing wearable electrochemical devices, such as sampling, data collection, connection protocols, and power sources, and discusses some critical challenges for higher performance in this field. We also present an overview of the application of paper as an intelligent substrate for electrochemical wearable sensors and discuss their advantages and drawbacks. Lastly, conclude by highlighting the future advances in wearable sensors and diagnostics by coupling real-time and on-body measurements to multiplexed detection of different biomarkers simultaneously, reducing the cost and time of classical analysis to provide fast and complete overall physiological conditions to the wearer. (AU)

FAPESP's process: 21/14732-0 - Development of electrochemical devices based on graphene obtained by advanced inkjet-printing and laser-scribing techniques as platforms to monitor biomarkers
Grantee:Patrícia Batista Deroco
Support Opportunities: Scholarships abroad - Research Internship - Post-doctor
FAPESP's process: 14/50867-3 - INCT 2014: National Institute of Science and Technology in Bioanalysis
Grantee:Lauro Tatsuo Kubota
Support Opportunities: Research Projects - Thematic Grants
FAPESP's process: 13/22127-2 - Development of novel materials strategic for integrated analytical devices
Grantee:Lauro Tatsuo Kubota
Support Opportunities: Research Projects - Thematic Grants
FAPESP's process: 19/00166-2 - Paper-Based Electrochemical Biosensor for Traumatic Brain Injury detection
Grantee:Patrícia Batista Deroco
Support Opportunities: Scholarships in Brazil - Post-Doctoral
FAPESP's process: 21/09706-0 - Development of a CRISPR/Cas-based electrochemical biosensor for T-Cell Leukemia virus (HTLV-1) and Staphylococcus Aureus bacteria detection with point-of-care devices
Grantee:Dagwin Wachholz Júnior
Support Opportunities: Scholarships in Brazil - Doctorate