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Computer-Aided Diagnosis of Vertebral Compression Fractures Using Convolutional Neural Networks and Radiomics

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Del Lama, Rafael Silva ; Candido, Raquel Mariana ; Chiari-Correia, Natalia Santana ; Nogueira-Barbosa, Marcello Henrique ; de Azevedo-Marques, Paulo Mazzoncini ; Tinos, Renato
Total Authors: 6
Document type: Journal article
Source: JOURNAL OF DIGITAL IMAGING; v. 35, n. 3, p. 13-pg., 2022-02-07.

Vertebral Compression Fracture (VCF) occurs when the vertebral body partially collapses under the action of compressive forces. Non-traumatic VCFs can be secondary to osteoporosis fragility (benign VCFs) or tumors (malignant VCFs). The investigation of the etiology of non-traumatic VCFs is usually necessary, since treatment and prognosis are dependent on the VCF type. Currently, there has been great interest in using Convolutional Neural Networks (CNNs) for the classification of medical images because these networks allow the automatic extraction of useful features for the classification in a given problem. However, CNNs usually require large datasets that are often not available in medical applications. Besides, these networks generally do not use additional information that may be important for classification. A different approach is to classify the image based on a large number of predefined features, an approach known as radiomics. In this work, we propose a hybrid method for classifying VCFs that uses features from three different sources: i) intermediate layers of CNNs; ii) radiomics; iii) additional clinical and image histogram information. In the hybrid method proposed here, external features are inserted as additional inputs to the first dense layer of a CNN. A Genetic Algorithm is used to: i) select a subset of radiomic, clinical, and histogram features relevant to the classification of VCFs; ii) select hyper-parameters of the CNN. Experiments using different models indicate that combining information is interesting to improve the performance of the classifier. Besides, pre-trained CNNs presents better performance than CNNs trained from scratch on the classification of VCFs. (AU)

FAPESP's process: 19/07665-4 - Center for Artificial Intelligence
Grantee:Fabio Gagliardi Cozman
Support Opportunities: Research Grants - Research Program in eScience and Data Science - Research Centers in Engineering Program
FAPESP's process: 19/01219-2 - Genetic algorithms and convolutional neural networks for computer-aided diagnosis of spinal compression fractures
Grantee:Rafael Silva Del Lama
Support Opportunities: Scholarships in Brazil - Master
FAPESP's process: 21/09720-2 - Design of gray-box evolutionary algorithms and applications
Grantee:Renato Tinós
Support Opportunities: Regular Research Grants