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(Reference retrieved automatically from Web of Science through information on FAPESP grant and its corresponding number as mentioned in the publication by the authors.)

ynergetic effect of silver nanoparticles and thiram on lipid bilayer

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Martin, Cibely S. [1] ; Oliveira, Marcelo J. S. [1] ; Maximino, Mateus D. [1] ; Pazin, Wallance M. [2, 1] ; Constantino, Carlos J. L. [1]
Total Authors: 5
[1] Sao Paulo State Univ UNESP, Sch Technol & Appl Sci, BR-19060080 Presidente Prudente, SP - Brazil
[2] Univ Sao Paulo, Sao Carlos Inst Phys, BR-13560970 Sao Carlos, SP - Brazil
Total Affiliations: 2
Document type: Journal article
Source: JOURNAL OF MOLECULAR LIQUIDS; v. 348, FEB 15 2022.
Web of Science Citations: 0

The excessive concentration of nanomaterials and pesticides in industrial products, food, and in the environment can be a risk to human health. Exposure to these materials can occur through inhalation, dermal contact, or oral ingestion, which depends directly on the type of products we are exposed to. Extensive studies about the individual action of these compounds have been described. However, the effect of these mixtures (nanoparticles and pesticides, for instance) requires more investigation. Here, we evaluated by phase-contrast microscopy the individual and mixture effects of silver nanoparticles (AgNp) and thiram pesticide on mimetic systems of the lipid bilayer structure of the plasma membrane using DOPC (1,2-dioleoyl-sn-glycero-3-phosphocholine) giant unilamellar vesicles (GUVs). Besides, the effect of thiram pesticide on DPPC (1,2-dipalmitoyl-sn-glycero-3-phosphocholine) multilamellar vesicles containing AgNp (encapsulated) was also evaluated by surface-enhanced Raman scattering (SERS). The results showed a synergetic effect of the AgNp and thiram mixture, which lead to a loss of phase contrast intensity and rupture of the lipid bilayers. The synergetic effect was ascribed to the strong interaction AgNp-thiram through Ag-S bond formation. (C) 2021 Elsevier B.V. All rights reserved. (AU)

FAPESP's process: 18/22214-6 - Towards a convergence of technologies: from sensing and biosensing to information visualization and machine learning for data analysis in clinical diagnosis
Grantee:Osvaldo Novais de Oliveira Junior
Support Opportunities: Research Projects - Thematic Grants
FAPESP's process: 17/15019-0 - Combination of confocal fluorescence microscopy and surface-enhanced Raman scattering techniques: interaction, detection, and quantification of molecules of interest in biomimetic system.
Grantee:Cibely da Silva Martin Sonvesso
Support Opportunities: Scholarships in Brazil - Post-Doctoral
FAPESP's process: 20/12129-1 - Immunoassay for COVID-19 diagnosis based on surface-enhanced Raman scattering technique
Grantee:Wallance Moreira Pazin
Support Opportunities: Scholarships in Brazil - Post-Doctoral