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(Reference retrieved automatically from Web of Science through information on FAPESP grant and its corresponding number as mentioned in the publication by the authors.)

e(III)-Based Layered Double Hydroxides Carrying Model Naproxenate Anions: Compositional and Structural Aspect

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Figueiredo, Mariana Pires [1] ; Cunha, Vanessa R. R. [1, 2] ; Cellier, Joel [3, 4] ; Taviot-Gueho, Christine [3, 4] ; Constantino, Vera R. L. [1]
Total Authors: 5
[1] Univ Sao Paulo, Inst Quim, Dept Quim Fundamental, Av Prof Lineu Prestes 748, BR-05508000 Sao Paulo, SP - Brazil
[2] Inst Fed Educ Ciencia & Tecnol Mato Grosso IFMT, Linha J S-No, BR-78320000 Juina, MT - Brazil
[3] Univ Clermont Auvergne, BP 10448, F-63000 Clermont Ferrand - France
[4] Inst Chim Clermont Ferrand, UMR 6296, CNRS, F-63178 Aubiere - France
Total Affiliations: 4
Document type: Journal article
Source: CHEMISTRYSELECT; v. 7, n. 1 JAN 11 2022.
Web of Science Citations: 0

In this work, Al cation was gradually replaced by Fe-III in the composition of Layered Double Hydroxides (LDH) and systematically investigated for LDH application as drug carriers, ultimate aiming to improve their biointegration. The incorporation of Fe-III into LDH layers, as well the intercalation of organic anions in the iron-based materials, is challenging. Several studies approach the intercalation of non-steroidal anti-inflammatory drugs such as anionic naproxen (NAP) into Al-LDH. Thus, NAP was applied here as a model drug for the study of compositional and structural aspects of novel Fe-III-LDH carriers envisaging to shed light on the intercalation of other carboxylate drugs into these materials. LDH of general {[}M2FeyAl(1-y)(OH)(6)]A(n-) compositions (M-II=Mg or Zn; A(n-)=anion of charge n) were investigated using two synthetic methods for NAP intercalation. Full X-ray diffraction profile refinement and a crystal-geometrical reasoning were used to strengthen the results interpretation. Unlike coprecipitation, in which probably NAP complexation with Fe-III hinders LDH-NAP self-assembling, topotactic ion exchange demonstrated to be a potential approach. (AU)

FAPESP's process: 16/13862-9 - Conception and development of drug nanocarriers based on layered double hydroxides
Grantee:Mariana Pires Figueiredo
Support Opportunities: Scholarships in Brazil - Doctorate (Direct)
FAPESP's process: 16/50317-9 - Biocompatible nanovectors based on hybrid lamellar materials and composites with polymers for drug release
Grantee:Vera Regina Leopoldo Constantino
Support Opportunities: Regular Research Grants
FAPESP's process: 14/15900-0 - Synthesis and characterization of layered double hydroxides consisting of essential metals for drug encapsulation
Grantee:Mariana Pires Figueiredo
Support Opportunities: Scholarships in Brazil - Scientific Initiation
FAPESP's process: 12/12209-9 - Inorganic carriers of bioactive substances: development, characterization, toxicity evaluation of in vitro delivery and in vivo absorption after oral administration
Grantee:Vanessa Roberta Rodrigues da Cunha
Support Opportunities: Scholarships in Brazil - Post-Doctoral