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(Reference retrieved automatically from Web of Science through information on FAPESP grant and its corresponding number as mentioned in the publication by the authors.)

emale Prostate Development: Morphological Analysis of the Budding Dynami

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Author(s):
dos Santos, Fernanda C. A. [1] ; Negre, Ana F. P. [1] ; Rodriguez, Daniel A. O. [2] ; de Sousa, Gessica C. [1] ; Rodrigues, Giovanna A. [1] ; Sanches, Bruno D. A. [2] ; Carvalho, Hernandes F. [2] ; Taboga, Sebastiao R. [3] ; Biancardi, Manoel F. [1]
Total Authors: 9
Affiliation:
[1] Univ Fed Goias, Dept Histol Embryol & Cell Biol, Campus Samambaia, BR-74690900 Goiania, Go - Brazil
[2] Univ Estadual Campinas, Dept Struct & Funct Biol, BR-13083862 Campinas, SP - Brazil
[3] State Univ Sao Paulo, Dept Biol, BR-15054000 Sao Jose Do Rio Preto, SP - Brazil
Total Affiliations: 3
Document type: Journal article
Source: Microscopy and Microanalysis; v. 28, n. 1, p. 272-280, FEB 2022.
Web of Science Citations: 0
Abstract

The presence of the prostate in female mammals has long been known. However, pieces of information related to its development are still lacking. The aim of this study was to explore the budding dynamic during the initial prostate development in female gerbils. Pregnant females were timed, the fetuses were euthanized, and the urogenital sinus was dissected out between the embryonic days 20 and 24 (E20-E24 groups). Newborn pups (1-day-old; P1 group) underwent the same procedures. The female prostate development was based on epithelial buds which arose far from the paraurethral mesenchyme (PAM). The epithelial buds reached the PAM at prenatal day 24, crossing a small gap in the smooth muscle layer between the periurethral mesenchyme (PEM) and the PAM. Steroid nuclear receptors such as the androgen receptor and estrogen receptor alpha were localized in the PEM through the urethral wall, although some epithelial labeling was also present in the urogenital sinus epithelium (UGE). P63-positive cells were found only in the UGE, becoming restricted to the basal compartment after the 23rd prenatal day. The results showed that the gerbil female prostate exhibits a distinct budding pattern as compared to the male prostate development. (AU)

FAPESP's process: 09/53990-2 - Acquisition of a confocal laser scanning microscope for a Multi-User Microscopy Center at São Paulo State University
Grantee:Sebastião Roberto Taboga
Support Opportunities: Multi-user Equipment Program
FAPESP's process: 11/06335-9 - Effects of intrauterine and puberal exposure to endocrine-disrupting chemicals on the old gerbils prostate
Grantee:Sebastião Roberto Taboga
Support Opportunities: Regular Research Grants
FAPESP's process: 11/20358-1 - The prostate ventral lobe organogenesis in the Mongolian gerbil (Meriones unguiculatus) during the prenatal period
Grantee:Bruno Domingos Azevedo Sanches
Support Opportunities: Scholarships in Brazil - Scientific Initiation
FAPESP's process: 09/16789-7 - Effects of intrauterine and pubertal testosterone cipyonate exposure on the male and female senile gerbil's prostate
Grantee:Manoel Francisco Biancardi
Support Opportunities: Scholarships in Brazil - Doctorate