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(Reference retrieved automatically from Web of Science through information on FAPESP grant and its corresponding number as mentioned in the publication by the authors.)

-Glycoprotein and Androgen Receptor Expression Reveals Independence of Canine Prostate Cancer from Androgen Hormone Stimulatio

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Cavalca, Alexandre Matheus Baesso [1] ; Brandi, Andressa [1] ; Fonseca-Alves, Ricardo Henrique [2] ; Laufer-Amorim, Renee [3] ; Fonseca-Alves, Carlos Eduardo [4, 1]
Total Authors: 5
[1] Sao Paulo State Univ UNESP, Sch Vet Med & Anim Sci, Dept Vet Surg & Anesthesiol, BR-18618687 Botucatu, SP - Brazil
[2] Fed Univ Goias UFG, Sch Elect Mech & Comp Engn, Dept Elect Engn, BR-74690900 Goiania, Go - Brazil
[3] Sao Paulo State Univ UNESP, Sch Vet Med & Anim Sci, Dept Vet Clin, BR-18618687 Botucatu, SP - Brazil
[4] Paulista Univ UNIP, Inst Hlth Sci, BR-17048290 Bauru, SP - Brazil
Total Affiliations: 4
Document type: Journal article
Web of Science Citations: 0

Canine prostate cancer (PC) is an aggressive disease, and dogs can be considered comparative models for human PC. In recent years, canine PC has been shown to resemble human castrate-resistant prostate cancer. The influx and efflux of testosterone in prostatic luminal cells are regulated by P-glycoprotein (P-gp). Therefore, human PC generally lacks P-gp expression and maintains the expression of androgen receptors (ARs). However, this co-expression has not previously been investigated in dogs. Therefore, this study aimed to evaluate AR and P-gp co-expression to elucidate these protein patterns in canine prostate samples. We identified AR/P-gp double immunofluorescence co-expression of both proteins in normal luminal cells. However, in canine PC, cells lack AR expression and exhibit increased P-gp expression. These results were confirmed by gene expression analyses. Overall, our results strongly suggest that normal canine prostate testosterone influx may be regulated by P-gp expression, and that during progression to PC, prostatic cells lack AR expression and P-gp overexpress. P-gp expression in canine PC may be related to a phenotype of multiple drug resistance. (AU)

FAPESP's process: 15/25400-7 - In vitro and molecular characterization of canine prostatic cells and evaluation of antitumor response against target drugs
Grantee:Carlos Eduardo Fonseca Alves
Support type: Scholarships in Brazil - Post-Doctorate