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(Reference retrieved automatically from Web of Science through information on FAPESP grant and its corresponding number as mentioned in the publication by the authors.)

lockade of caspase cascade overcomes malaria-associated acute respiratory distress syndrome in mic

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Sercundes, Michelle K. [1] ; Ortolan, Luana S. [2, 3] ; Julio, Viviane da Silva [1] ; Bella, Leonardo M. [1] ; Quirino, Thatyane de Castro [1] ; Debone, Daniela [1] ; Carneiro-Ramos, Marcela S. [4] ; Christoffolete, Marcelo A. [4] ; Martins, Joilson O. [1] ; D'Imperio Lima, Maria Regina [2] ; Alvarez, Jose M. [2] ; Amarante-Mendes, Gustavo P. [2, 5] ; Goncalves, Ligia Antunes [6] ; Marinho, Claudio R. F. [6] ; Epiphanio, Sabrina [1]
Total Authors: 15
[1] Univ Sao Paulo, Fac Ciencias Farmaceut, Dept Anal Clin & Toxicol, Sao Paulo - Brazil
[2] Univ Sao Paulo, Inst Ciencias Biomed, Dept Imunol, Sao Paulo - Brazil
[3] Seattle Childrens Res Inst, Ctr Global Infect Dis, Seattle, WA - USA
[4] Univ Fed ABC, Ctr Ciencias Nat & Humanas, Sao Paulo - Brazil
[5] Inst Nacl Ciencia & Tecnol INCT III, Inst Invest Imunol, Sao Paulo - Brazil
[6] Univ Sao Paulo, Inst Ciencias Biomed, Dept Parasitol, Sao Paulo - Brazil
Total Affiliations: 6
Document type: Journal article
Source: CELL DEATH & DISEASE; v. 13, n. 2 FEB 10 2022.
Web of Science Citations: 0

Malaria is an enormous burden on global health that caused 409,000 deaths in 2019. Severe malaria can manifest in the lungs, an illness known as acute respiratory distress syndrome (ARDS). Not much is known about the development of malaria-associated ARDS (MA-ARDS), especially regarding cell death in the lungs. We had previously established a murine model that mimics various human ARDS aspects, such as pulmonary edema, hemorrhages, pleural effusion, and hypoxemia, using DBA/2 mice infected with Plasmodium berghei ANKA. Here, we explored the mechanisms and the involvement of apoptosis in this syndrome. We found that apoptosis contributes to the pathogenesis of MA-ARDS, primarily as facilitators of the alveolar-capillary barrier breakdown. The protection of pulmonary endothelium by inhibiting caspase activation could be a promising therapeutic strategy to prevent the pathogenicity of MA-ARDS. Therefore, intervention in the programmed death cell mechanism could help patients not to develop severe malaria. (AU)

FAPESP's process: 20/03163-1 - Pulmonary proteomic profile of malaria-associated acute respiratory distress syndrome: identification and validation of biomarkers
Grantee:Sabrina Epiphanio
Support type: Regular Research Grants
FAPESP's process: 13/20718-3 - The role of cytoadherence and Toll-like receptors (TLRs) in the immunopathogenesis of murine severe malaria associated acute respiratory distress syndrome
Grantee:Luana dos Santos Ortolan
Support type: Scholarships in Brazil - Doctorate
FAPESP's process: 15/06106-0 - The role of inflammasomes in the pathogenesis of malaria during pregnancy: effects and mechanisms
Grantee:Cláudio Romero Farias Marinho
Support type: Research Grants - Visiting Researcher Grant - International
FAPESP's process: 20/06747-4 - Study of the humoral immune response in recurrent infections by Plasmodium vivax in pregnant women from Amazon region
Grantee:Cláudio Romero Farias Marinho
Support type: Regular Research Grants
FAPESP's process: 20/03175-0 - Investigating mechanisms that link angiotensins to obesity and diabetes
Grantee:Joilson de Oliveira Martins
Support type: Regular Research Grants