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(Reference retrieved automatically from Web of Science through information on FAPESP grant and its corresponding number as mentioned in the publication by the authors.)

he preventive and therapeutic potential of native Brazilian fruits on colorectal cance

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do Nascimento, Roberto de Paula [1] ; Reguengo, Livia Mateus [1] ; da Fonseca Machado, Ana Paula [1] ; Marostica Junior, Mario Roberto [1]
Total Authors: 4
[1] Univ Estadual Campinas, Sch Food Engn, Monteiro Lobato St 80, BR-13083862 Campinas, SP - Brazil
Total Affiliations: 1
Document type: Journal article
Source: FOOD BIOSCIENCE; v. 46, APR 2022.
Web of Science Citations: 0

In the last years, colorectal cancer (CRC) has been increasing substantially in developing countries. While the consumption of fat and meat have been linked with increased CRC risk, fruits intake can be protective. In addition, since CRC's chemotherapy may be accompanied with adverse effects, natural plant products have been postulated as alternative or complementary therapeutic options. Brazilian fruits are rich sources of bioactive compounds, mainly phenolic compounds, with antioxidant, anti-inflammatory, and anticancer benefits, thus, future candidates for CRC management. Therefore, this narrative review aims to present and discuss the potential of native Brazilian fruits (e.g., acai, cocoa, jaboticaba, passionfruit) on CRC. Experimental studies performed from 2001 to present were considered. Polyphenol-rich powders and extracts from Brazilian fruits are the most promising products for CRC management. Studies with acai (Euterpe oleracea) and cocoa (Theobroma cacao) are more numerous and their effects on CRC models in vitro and in vivo are demonstrated with more complexity in terms of molecular mechanisms. The main signaling pathways modulated by the effects of native Brazilian fruits, so far studied on CRC, are associated with: 1. apoptosis (B-cell lymphoma 2- and caspase 3-related proteins), 2. inflammation (pro-inflammatory interleukins and enzymes), and 3. oxidative stress (antioxidant enzymes). In addition, adhesion molecules and nuclear factor kappa B have been shown to be downregulated, which can interfere positively in several cellular processes, including proliferation, angiogenesis, and migration. The investigation of signaling pathways of great relevance for CRC initiation and progression is still necessary. (AU)

FAPESP's process: 18/11069-5 - Action of Brazilian berries on metabolic parameters and cognitive performance of obese animals
Grantee:Mário Roberto Maróstica Junior
Support Opportunities: Regular Research Grants
FAPESP's process: 19/03228-9 - Preventive effects of the consumption of freeze-dried jaboticaba peel in BALB/c mice with Colorectal Cancer induced by azoxymethane/dextran sodium sulfate
Grantee:Roberto de Paula do Nascimento
Support Opportunities: Scholarships in Brazil - Doctorate
FAPESP's process: 17/23657-6 - Development of microparticles containing grape skin extract through the emerging technique SAS and evaluation of their antioxidant and anti-inflammatory effects in the treatment of induced Colitis in rats
Grantee:Ana Paula da Fonseca Machado
Support Opportunities: Scholarships in Brazil - Post-Doctorate
FAPESP's process: 15/50333-1 - COBRA: a novel compound discovery pipeline for rapid and cost-effective identification of bioactives with health beneficial effects in Brazilian crops
Grantee:Glaucia Maria Pastore
Support Opportunities: Research Projects - Thematic Grants
FAPESP's process: 19/25048-2 - Bioaccessibility of jaboticaba peel in dinamic colonic model and anti-inflammatory effect in macrophages
Grantee:Livia Mateus Reguengo
Support Opportunities: Scholarships in Brazil - Doctorate (Direct)
FAPESP's process: 15/13320-9 - Effect of pulp oil and tea of leaves from avocado Hass variety associated with physical activity in the treatment of obesity induced by high-fat diet
Grantee:Mário Roberto Maróstica Junior
Support Opportunities: Regular Research Grants