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(Reference retrieved automatically from Web of Science through information on FAPESP grant and its corresponding number as mentioned in the publication by the authors.)

ngestion of orange juice prevents hyperglycemia and increases plasma miR-375 expressio

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Quintanilha, Bruna J. [1, 2] ; Chaves, Daniela F. S. [3] ; Brasili, Elisa [4] ; Correa, Telma A. F. [2, 3] ; Capetini, Vinicius Cooper [1, 2] ; Ferreira, Frederico Moraes [5] ; Castro, Inar A. [2, 3] ; Hassimotto, Neuza M. A. [2, 3] ; Rogero, Marcelo M. [1, 2] ; Lajolo, Franco M. [2, 3]
Total Authors: 10
[1] Univ Sao Paulo, Sch Publ Hlth, Dept Nutr, Sao Paulo - Brazil
[2] CEPID FAPESP Res Innovat & Disseminat Ctr Sao Pau, Food Res Ctr FoRC, Sao Paulo - Brazil
[3] Univ Sao Paulo, Dept Food Sci & Expt Nutr, Sch Pharmaceut Sci, Sao Paulo - Brazil
[4] Sapienza Univ Rome, Dept Environm Biol, Rome - Italy
[5] Univ Sao Paulo, Div Pathol, Sch Med, Sao Paulo - Brazil
Total Affiliations: 5
Document type: Journal article
Source: CLINICAL NUTRITION ESPEN; v. 47, p. 240-245, FEB 2022.
Web of Science Citations: 0

Background \& aims: The intake of high-fat, high-carbohydrate (HFHC) meals is associated with an increased risk of type 2 diabetes. There is evidence that the association of orange juice to a HFHC meal can modulate the expression of microRNAs (miRNAs) linked to pancreatic beta-cell function such as miR-375. We evaluated the effect of a commercial orange juice intake with HFHC meal on plasma miRNAs expression in twelve healthy subjects in a crossover design study. Methods: Subjects ingested water, orange juice, or an isocaloric beverage along with a 1037 kcal HFHC meal. Blood glucose and miRNAs were evaluated at baseline and 1, 3, and 5 h after the intake. Results: The area under the curve (AUC) for glycemia after ingestion of HFHC + orange juice did not differ from ingestion of HPHC + glucose or HFHC + water. However, the AUC was higher in HFHC meal + glucose compared to HFHC meal + water (p = 0.034). Glucose and insulin concentrations were significantly higher in HFHC meal + glucose group after 1 h, when compared with other groups and times (p < 0.001). There was an increase in plasma miR-375 expression after 3 h of ingestion of HFHC + orange juice versus water (p = 0.026), and a decrease in plasma miR-205-5p expression after HFHC meal + glucose versus water (p = 0.023). Conclusions: A single HFHC meal + orange juice modulated plasma miR-375 expression, which is a biomarker of pancreatic beta-cell function, and contributed to preventing hyperglycemia. (C) 2021 European Society for Clinical Nutrition and Metabolism. Published by Elsevier Ltd. All rights reserved. (AU)

FAPESP's process: 14/22864-0 - Biomarkers identification of dietary polyphenols intake using metabolome and proteome approaches
Grantee:Daniela Fojo Seixas Chaves
Support Opportunities: Scholarships in Brazil - Post-Doctoral
FAPESP's process: 13/07914-8 - FoRC - Food Research Center
Grantee:Bernadette Dora Gombossy de Melo Franco
Support Opportunities: Research Grants - Research, Innovation and Dissemination Centers - RIDC