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(Reference retrieved automatically from Web of Science through information on FAPESP grant and its corresponding number as mentioned in the publication by the authors.)

eeping the host alive - lessons from obligate intracellular bacterial pathogen

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Loterio, Robson Kriiger [1, 2] ; Zamboni, Dario S. [1] ; Newton, Hayley J. [2]
Total Authors: 3
[1] Univ Sao Paulo, Fac Med Ribeirao Preto, Ribeirao Preto Med Sch, Dept Biol Celular & Mol & Bioagentes Patogen, FMRP, Av Bandeirantes 3900, BR-14049900 Ribeirao Preto, SP - Brazil
[2] Univ Melbourne, Dept Microbiol & Immunol, Peter Doherty Inst Infect & Immun, 792 Elizabeth St, Melbourne, Vic 3000 - Australia
Total Affiliations: 2
Document type: Review article
Source: PATHOGENS AND DISEASE; v. 79, n. 9 DEC 2021.
Web of Science Citations: 1

Mammals have evolved sophisticated host cell death signaling pathways as an important immune mechanism to recognize and eliminate cell intruders before they establish their replicative niche. However, intracellular bacterial pathogens that have co-evolved with their host have developed a multitude of tactics to counteract this defense strategy to facilitate their survival and replication. This requires manipulation of pro-death and pro-survival host signaling pathways during infection. Obligate intracellular bacterial pathogens are organisms that absolutely require an eukaryotic host to survive and replicate, and therefore they have developed virulence factors to prevent diverse forms of host cell death and conserve their replicative niche. This review encapsulates our current understanding of these host-pathogen interactions by exploring the most relevant findings of Anaplasma spp., Chlamydia spp., Rickettsia spp. and Coxiella burnetii modulating host cell death pathways. A detailed comprehension of the molecular mechanisms through which these obligate intracellular pathogens manipulate regulated host cell death will not only increase the current understanding of these difficult-to-study pathogens but also provide insights into new tools to study regulated cell death and the development of new therapeutic approaches to control infection. (AU)

FAPESP's process: 16/24275-7 - Identification of Coxiella burnetii proteins involved in the modulation of the inflammasome activasion and in the intracellular signaling pathways in macrophages
Grantee:Robson Kriiger Loterio
Support Opportunities: Scholarships in Brazil - Doctorate (Direct)
FAPESP's process: 14/04684-4 - The inflammasome in the host response against intracellular pathogens and the microbial mechanisms for its evasion
Grantee:Dario Simões Zamboni
Support Opportunities: Research Projects - Thematic Grants
FAPESP's process: 19/11342-6 - Mechanisms and consequences of the activation of cytoplasmic receptors by intracellular pathogens
Grantee:Dario Simões Zamboni
Support Opportunities: Research Projects - Thematic Grants