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(Reference retrieved automatically from Web of Science through information on FAPESP grant and its corresponding number as mentioned in the publication by the authors.)

olid lipid nanoparticles loaded with curcumin: development and in vitro toxicity against CT26 cell

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Ganassin, Rayane [1, 2] ; da Silva, Victor Carlos Mello [1, 2] ; Araujo, Victor Hugo Sousa [1, 2] ; Tavares, Giulia Rosa [1, 2] ; da Silva, Patricia Bento [1] ; Caceres-Velez, Paolin Rocio [1, 3, 2, 4] ; Porcel, Joaquin E. Martinez [4] ; Rodrigues, Mosar Correa [1] ; Andreozzi, Patrizia [4] ; Fernandes, Richard Perosa [5] ; Fonseca-Santos, Bruno [6] ; Moya, Sergio [4] ; Azevedo, Ricardo Bentes [1] ; Chorilli, Marlus [7] ; Muehlmann, Luis Alexandre [1, 2]
Total Authors: 15
[1] Univ Brasilia, Inst Biol Sci, Dept Genet & Morphol, BR-70910900 Brasilia, DF - Brazil
[2] Univ Brasilia, Fac Ceilandia, Lab Nanosci & Immunol, BR-72220900 Brasilia, DF - Brazil
[3] Univ Melbourne, Sch BioSci, Parkville, Vic 3010 - Australia
[4] Ctr Cooperat Res Biomat CIC BiomaGUNE, Soft Matter Lab, San Sebastian - Spain
[5] Sa Paulo State Univ, Chem Inst, Lab Thermal Anal Ivo Giolitto, Araraquara, SP - Brazil
[6] Univ Campinas UNICAMP, BR-13083871 Campinas, SP - Brazil
[7] Sao Paulo State Univ UNESP, Sch Pharmaceut Sci, BR-14800903 Araraquara, SP - Brazil
Total Affiliations: 7
Document type: Journal article
Source: Nanomedicine; v. 17, n. 3, p. 167-179, FEB 2022.
Web of Science Citations: 0

Aim: To develop a new curcumin carrier consisting of murumuru butter nanoparticles (SLN-Cs). Methods: A phase-inversion temperature method was used to produce SLN-Cs. The interaction of SLN-Cs with murine colon adenocarcinoma (CT26) cells in vitro was analyzed by confocal microscopy. Results: Stable SLN-Cs with a high curcumin-loading capacity were obtained. The SLN-Cs were more toxic to CT26 than free curcumin. Fluorescence microscopy images showed the SLN-Cs to be taken up by CT26 cells in vitro. Conclusion: These results indicate that SLN-Cs are suitable carriers of curcumin in aqueous media. (AU)

FAPESP's process: 19/10261-2 - Evaluation of the potential of nanostructured lipid carriers for co-encapsulation of curcumin and fluconazole dispersed in thermally-responsive hydrogels in the treatment of vulvovaginal candidiasis
Grantee:Victor Hugo Sousa Araujo
Support type: Scholarships in Brazil - Doctorate