Yates, Abi G.
Pink, Ryan C.
Siljander, Pia R-M.
Dellar, Elizabeth R.
Cooke, William R.
Anthony, Daniel C.
Total Authors: 12
 Univ Oxford, Dept Pharmacol, Oxford - England
 Univ Queensland, Sch Biomed Sci, Fac Med, St Lucia, Qld - Australia
 Oxford Brookes Univ, Fac Hlth & Life Sci, Dept Biol & Med Sci, Oxford - England
 Univ Virginia, Dept Med, Div Nephrol, Charlottesville, VA - USA
 Univ Helsinki, Fac Biol & Environm Sci, Mol & Integrat Biosci Res Programme, Helsinki - Finland
 Univ Oxford, Div Cardiovasc Med, Radcliffe Dept Med, Oxford - England
 John Radcliffe Hosp, Nuffield Dept Womens & Reprod Hlth, Oxford - England
 AC Camargo Canc Ctr, Lab Med Genom, Sao Paulo - Brazil
 Sao Paulo Med Sch, Inst Psychiat, Lab Neurosci LIM 27, Sao Paulo - Brazil
JOURNAL OF EXTRACELLULAR VESICLES;
Web of Science Citations:
It is clear from Part I of this series that extracellular vesicles (EVs) play a critical role in maintaining the homeostasis of most, if not all, normal physiological systems. However, the majority of our knowledge about EV signalling has come from studying them in disease. Indeed, EVs have consistently been associated with propagating disease pathophysiology. The analysis of EVs in biofluids, obtained in the clinic, has been an essential of the work to improve our understanding of their role in disease. However, to interfere with EV signalling for therapeutic gain, a more fundamental understanding of the mechanisms by which they contribute to pathogenic processes is required. Only by discovering how the EV populations in different biofluids change-size, number, and physicochemical composition-in clinical samples, may we then begin to unravel their functional roles in translational models in vitro and in vivo, which can then feedback to the clinic. In Part II of this review series, the functional role of EVs in pathology and disease will be discussed, with a focus on in vivo evidence and their potential to be used as both biomarkers and points of therapeutic intervention. (AU)