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(Reference retrieved automatically from Web of Science through information on FAPESP grant and its corresponding number as mentioned in the publication by the authors.)

n sickness and in health: The functional role of extracellular vesicles in physiology and pathology in vivo Part II: Patholog

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Yates, Abi G. [1, 2] ; Pink, Ryan C. [3] ; Erdbrugger, Uta [4] ; Siljander, Pia R-M. [5] ; Dellar, Elizabeth R. [3] ; Pantazi, Paschalia [3] ; Akbar, Naveed [6] ; Cooke, William R. [7] ; Vatish, Manu [7] ; Dias-Neto, Emmanuel [8, 9] ; Anthony, Daniel C. [1] ; Couch, Yvonne [10]
Total Authors: 12
[1] Univ Oxford, Dept Pharmacol, Oxford - England
[2] Univ Queensland, Sch Biomed Sci, Fac Med, St Lucia, Qld - Australia
[3] Oxford Brookes Univ, Fac Hlth & Life Sci, Dept Biol & Med Sci, Oxford - England
[4] Univ Virginia, Dept Med, Div Nephrol, Charlottesville, VA - USA
[5] Univ Helsinki, Fac Biol & Environm Sci, Mol & Integrat Biosci Res Programme, Helsinki - Finland
[6] Univ Oxford, Div Cardiovasc Med, Radcliffe Dept Med, Oxford - England
[7] John Radcliffe Hosp, Nuffield Dept Womens & Reprod Hlth, Oxford - England
[8] AC Camargo Canc Ctr, Lab Med Genom, Sao Paulo - Brazil
[9] Sao Paulo Med Sch, Inst Psychiat, Lab Neurosci LIM 27, Sao Paulo - Brazil
[10] Univ Oxford, Radcliffe Dept Med, Acute Stroke Programme, Oxford - England
Total Affiliations: 10
Document type: Review article
Web of Science Citations: 0

It is clear from Part I of this series that extracellular vesicles (EVs) play a critical role in maintaining the homeostasis of most, if not all, normal physiological systems. However, the majority of our knowledge about EV signalling has come from studying them in disease. Indeed, EVs have consistently been associated with propagating disease pathophysiology. The analysis of EVs in biofluids, obtained in the clinic, has been an essential of the work to improve our understanding of their role in disease. However, to interfere with EV signalling for therapeutic gain, a more fundamental understanding of the mechanisms by which they contribute to pathogenic processes is required. Only by discovering how the EV populations in different biofluids change-size, number, and physicochemical composition-in clinical samples, may we then begin to unravel their functional roles in translational models in vitro and in vivo, which can then feedback to the clinic. In Part II of this review series, the functional role of EVs in pathology and disease will be discussed, with a focus on in vivo evidence and their potential to be used as both biomarkers and points of therapeutic intervention. (AU)

FAPESP's process: 14/26897-0 - Epidemiology and genomics of gastric adenocarcinomas in Brazil
Grantee:Emmanuel Dias-Neto
Support Opportunities: Research Projects - Thematic Grants
FAPESP's process: 15/50257-3 - Extracellular vesicles and non-cellular RNA: roles in health and neglected tropical diseases | São Paulo - SP
Grantee:Emmanuel Dias-Neto
Support Opportunities: Organization Grants - Scientific Meeting
FAPESP's process: 11/09172-3 - Evaluation of circulating microparticles derived from invasive ductal breast adenocarcinomas Her2+ patients and it's possible correlation with tumor aggressiveness
Grantee:Emmanuel Dias-Neto
Support Opportunities: Regular Research Grants