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(Reference retrieved automatically from Web of Science through information on FAPESP grant and its corresponding number as mentioned in the publication by the authors.)

novel hypermucoviscous Klebsiella pneumoniae ST3994-K2 clone belonging to Clonal Group 8

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Author(s):
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Cerdeira, Louise [1, 2] ; Nakamura-Silva, Rafael [3] ; Oliveira-Silva, Mariana [3] ; Sano, Elder [4, 5] ; Esposito, Fernanda [5, 6] ; Fuga, Bruna [4, 5] ; Moura, Quezia [7] ; Saraiva Miranda, Carlos Eduardo [8] ; Wyres, Kelly [1] ; Lincopan, Nilton [4, 5, 6] ; Pitondo-Silva, Andre [3, 8]
Total Authors: 11
Affiliation:
[1] Monash Univ, Cent Clin Sch, Dept Infect Dis, Melbourne, Vic 3800 - Australia
[2] Univ Liverpool Liverpool Sch Trop Med, Dept Vector Biol, Liverpool L3 5QA, Merseyside - England
[3] Univ Ribeirao Preto, Postgrad Program Environm Technol, BR-14096900 Ribeirao Preto, SP - Brazil
[4] Univ Sao Paulo, Inst Biomed Sci, BR-05508000 Sao Paulo, SP - Brazil
[5] Univ Sao Paulo, One Hlth Brazilian Resistance Project OneBR, BR-05508000 Sao Paulo, SP - Brazil
[6] Univ Sao Paulo, Sch Pharm, Dept Clin Anal, BR-05508000 Sao Paulo, SP - Brazil
[7] Fed Inst Educ Sci & Technol Espirito Santo, BR-29106010 Vila Velha - Brazil
[8] Univ Ribeirao Preto, Postgrad Program Dent, BR-14096900 Ribeirao Preto, SP - Brazil
Total Affiliations: 8
Document type: Journal article
Source: PATHOGENS AND DISEASE; v. 79, n. 8 NOV 2021.
Web of Science Citations: 0
Abstract

Emergent hypervirulent Klebsiella pneumoniae has been responsible for severe diseases, representing a serious threat to public health. We report the whole-genome sequencing of a novel ST3994-K2 clone, a single locus variant of ST86 K2, which is considered a worrying hypervirulent clone that emerged in several parts of the world. The strain K. pneumonia Kpi144 was isolated in 2013 from a blood culture of a 69-year-old male patient admitted to a tertiary hospital in Teresina, state of Piaui, northeastern Brazil. The strain was susceptible to 41 antibiotics tested, presented hypermucoviscous phenotype and a virulent behavior was observed in the Galleria mellonella infection model. Moreover, the virulome showed several virulence genes. To the best of our knowledge, this is the first worldwide report of a novel ST3994-K2 K. pneumoniae clone, an SLV of ST86 K2, which is considered a worrying virulent clone that has emerged in several parts of the world, including South America and Brazil. (AU)

FAPESP's process: 13/22581-5 - Study of pathogenic mechanisms and correlation with antimicrobial resistance of Klebsiella pneumoniae from Brazil and other countries across five continents
Grantee:André Pitondo da Silva
Support Opportunities: Research Grants - Young Investigators Grants