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(Reference retrieved automatically from Web of Science through information on FAPESP grant and its corresponding number as mentioned in the publication by the authors.)

Interaction of periodontitis and orthodontic tooth movement-an in vitro and in vivo study

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Author(s):
Rath-Deschner, Birgit [1] ; Nogueira, Andressa V. B. [2] ; Beisel-Memmert, Svenja [1] ; Nokhbehsaim, Marjan [3] ; Eick, Sigrun [4] ; Cirelli, Joni A. [5] ; Deschner, James [2] ; Jaeger, Andreas [1] ; Damanaki, Anna [2]
Total Authors: 9
Affiliation:
[1] Univ Bonn, Ctr Dentomaxillofacial Med, Dept Orthodont, Welschnonnenstr 17, D-53111 Bonn - Germany
[2] Johannes Gutenberg Univ Mainz, Dept Periodontol & Operat Dent, Univ Med Ctr, Mainz - Germany
[3] Univ Bonn, Ctr Dentomaxillofacial Med, Sect Expt Dentomaxillofacial Med, Bonn - Germany
[4] Univ Bern, Dept Periodontol, Lab Oral Microbiol, Bern - Switzerland
[5] Sao Paulo State Univ, Sch Dent Araraquara, Dept Diag & Surg, UNESP, Araraquara, SP - Brazil
Total Affiliations: 5
Document type: Journal article
Source: CLINICAL ORAL INVESTIGATIONS; v. 26, n. 1, p. 171-181, JAN 2022.
Web of Science Citations: 1
Abstract

Objectives The aim of this in vitro and in vivo study was to investigate the interaction of periodontitis and orthodontic tooth movement on interleukin (IL)-6 and C-X-C motif chemokine 2 (CXCL2). Materials and methods The effect of periodontitis and/or orthodontic tooth movement (OTM) on alveolar bone and gingival IL-6 and CXCL2 expressions was studied in rats by histology and RT-PCR, respectively. The animals were assigned to four groups (control, periodontitis, OTM, and combination of periodontitis and OTM). The IL-6 and CXCL2 levels were also studied in human gingival biopsies from periodontally healthy and periodontitis subjects by RT-PCR and immunohistochemistry. Additionally, the synthesis of IL-6 and CXCL2 in response to the periodontopathogen Fusobacterium nucleatum and/or mechanical strain was studied in periodontal fibroblasts by RT-PCR and ELISA. Results Periodontitis caused an increase in gingival levels of IL-6 and CXCL2 in the animal model. Moreover, orthodontic tooth movement further enhanced the bacteria-induced periodontal destruction and gingival IL-6 gene expression. Elevated IL-6 and CXCL2 gingival levels were also found in human periodontitis. Furthermore, mechanical strain increased the stimulatory effect of F. nucleatum on IL-6 protein in vitro. Conclusions Our study suggests that orthodontic tooth movement can enhance bacteria-induced periodontal inflammation and thus destruction and that IL-6 may play a pivotal role in this process. (AU)

FAPESP's process: 14/20715-7 - INFLUENCE OF ORTHODONTIC TOOTH MOVEMENT ON PERIODONTAL DISEASE PROGRESSION IN NORMAL SYSTEMIC HEALTH OR IN OBESITY
Grantee:Andressa Vilas Boas Nogueira
Support Opportunities: Scholarships in Brazil - Post-Doctoral
FAPESP's process: 17/07137-2 - Effects of obesity on periodontal tissues subjected to biomechanical forces
Grantee:Joni Augusto Cirelli
Support Opportunities: Regular Research Grants