Advanced search
Start date
(Reference retrieved automatically from Web of Science through information on FAPESP grant and its corresponding number as mentioned in the publication by the authors.)

Effect of Carnosine or beta-Alanine Supplementation on Markers of Glycemic Control and Insulin Resistance in Humans and Animals: A Systematic Review and Meta-analysis

Full text
Matthews, Joseph J. [1, 2] ; Dolan, Eimear [3] ; Swinton, Paul A. [4] ; Santos, Livia [1] ; Artioli, Guilherme G. [5, 3] ; Turner, Mark D. [6] ; Elliott-Sale, Kirsty J. [1] ; Sale, Craig [1]
Total Authors: 8
[1] Nottingham Trent Univ, Sport Hlth & Performance Enhancement SHAPE Res Ct, Sch Sci & Technol, Musculoskeletal Physiol Res Grp, Nottingham - England
[2] Birmingham City Univ, Res Ctr Life & Sport Sci CLaSS, Sch Hlth & Life Sci, Dept Sport & Exercise, Birmingham, W Midlands - England
[3] Univ Sao Paulo, Sch Phys Educ & Sport, Appl Physiol & Nutr Res Grp, Sao Paulo - Brazil
[4] Robert Gordon Univ, Sch Hlth Sci, Aberdeen - Scotland
[5] Univ Sao Paulo, Fac Med FMUSP, Rheumatol Div, Sao Paulo - Brazil
[6] Nottingham Trent Univ, Ctr Diabet Chron Dis & Ageing, Sch Sci & Technol, Nottingham - England
Total Affiliations: 6
Document type: Review article
Source: ADVANCES IN NUTRITION; v. 12, n. 6, p. 2216-2231, NOV 2021.
Web of Science Citations: 1

There is growing evidence that supplementation with carnosine, or its rate-limiting precursor beta-alanine, can ameliorate aspects of metabolic dysregulation that occur in diabetes and its related conditions. The purpose of this systematic review and meta-analysis was to evaluate the effect of carnosine or beta-alanine supplementation on markers of glycemic control and insulin resistance in humans and animals. We performed a systematic search of 6 electronic databases up to 31 December 2020. Primary outcomes were changes in 1) fasting glucose, 2) glycated hemoglobin (HbA1c), and 3) 2-h glucose following a glucose-tolerance test. A set of additional outcomes included fasting insulin and homeostatic model assessment of beta-cell function (HOMA-beta) and insulin resistance (HOMA-IR). We assessed risk of bias using the Cochrane risk of bias (RoB) 2.0 (human studies) and the Systematic Review Center for Laboratory Animal Experimentation (SYRCLE) RoB (animal studies) tools; and used the Grading of Recommendations Assessment, Development, and Evaluation (GRADE) approach to assess certainty. We used Bayesian hierarchical random- effects models, with informative priors for human data and noninformative priors for animal data. Inferences were made on posterior samples generated by Hamiltonian Markov Chain Monte Carlo using 90% credible intervals (90% CrI) and calculated probabilities. Twenty studies (n=4 human, n=16 rodent) were included, providing data for 2 primary outcomes (fasting glucose and HbA1c) and 3 additional outcomes (fasting insulin, HOMA-beta, and HOMA-IR). Themodel provides evidence that supplementation decreases fasting glucose {[}humans: mean difference (MD)(0.5) =-0.95 mmol . L-1 (90% CrI: -2.1, 0.08); rodent: MD0.5 =-2.26 mmol . L-1 (90% CrI: -4.03, -0.44)], HbA1c {[}humans: MD0.5 =-0.91% (90% CrI: -1.46, -0.39); rodents: MD0.5 =-1.05% (90% CrI: -1.64, -0.52)], HOMA-IR {[}humans: standardizedmean difference (SMD)(0.5) =-0.41 (90% CrI: -0.82, -0.07); rodents: SMD0.5 =-0.63 (90% CrI: -1.98, 0.65)], and fasting insulin {[}humans: SMD0.5 =-0.41 (90% CrI: -0.77, -0.07)]. GRADE assessment showed our certainty in the effect estimate of each outcome to be moderate (human outcomes) or very low (rodent outcomes). Supplementation with carnosine or beta-alanine may reduce fasting glucose, HbA1c, and HOMA-IR in humans and rodents, and fasting insulin in humans; both compounds show potential as therapeutics to improve glycemic control and insulin resistance. (AU)

FAPESP's process: 14/11948-8 - Life without carnosine: development and characterization of a KO rat model for studying the physiological role of carnosine and its implications to physical exercise and muscle metabolism
Grantee:Guilherme Giannini Artioli
Support Opportunities: Research Grants - Young Investigators Grants
FAPESP's process: 19/26899-6 - The bone response to exercise a translational research program exploring clinical and mechanistic aspects
Grantee:Eimear Bernadette Dolan
Support Opportunities: Scholarships in Brazil - Young Researchers
FAPESP's process: 19/05616-6 - The bone response to exercise: a translational research program exploring clinical and mechanistic aspects
Grantee:Eimear Bernadette Dolan
Support Opportunities: Research Grants - Young Investigators Grants
FAPESP's process: 19/25032-9 - The role of carnosine on Ca2+ handling, control of oxidative stress and protection against protein glycation: advances and applications of the study life without carnosine
Grantee:Hamilton Augusto Roschel da Silva
Support Opportunities: Regular Research Grants