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(Reference retrieved automatically from Web of Science through information on FAPESP grant and its corresponding number as mentioned in the publication by the authors.)

In sickness and in health: The functional role of extracellular vesicles in physiology and pathology in vivo Part I: Health and Normal Physiology

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Yates, Abi G. [1, 2] ; Pink, Ryan C. [3] ; Erdbrugger, Uta [4] ; Siljander, Pia R-M. [5] ; Dellar, Elizabeth R. [3] ; Pantazi, Paschalia [3] ; Akbar, Naveed [6] ; Cooke, William R. [7] ; Vatish, Manu [7] ; Dias-Neto, Emmanuel [8, 9] ; Anthony, Daniel C. [1] ; Couch, Yvonne [10]
Total Authors: 12
[1] Univ Oxford, Dept Pharmacol, Oxford - England
[2] Univ Queensland, Fac Med, Sch Biomed Sci, St Lucia, Qld - Australia
[3] Oxford Brookes Univ, Fac Hlth & Life Sci, Dept Biol & Med Sci, Headington Campus, Oxford - England
[4] Univ Virginia, Dept Med, Div Nephrol, Charlottesville, VA - USA
[5] Univ Helsinki, Fac Biol & Environm Sci, Mol & Integrat Biosci Res Programme, Helsinki - Finland
[6] Univ Oxford, Radcliffe Dept Med, Div Cardiovasc Med, Oxford - England
[7] Univ Oxford, Nuffield Dept Womens & Reprod Hlth, Oxford - England
[8] AC Camargo Canc Ctr, Lab Med Genom, Sao Paulo - Brazil
[9] Sao Paulo Med Sch, Inst Psychiat, Lab Neurosci LIM 27, Sao Paulo - Brazil
[10] Univ Oxford, John Radcliffe Hosp, Acute Stroke Programme, Radcliffe Dept Med, Oxford OX3 9DU - England
Total Affiliations: 10
Document type: Review article
Web of Science Citations: 0

Previously thought to be nothing more than cellular debris, extracellular vesicles (EVs) are now known to mediate physiological and pathological functions throughout the body. We now understand more about their capacity to transfer nucleic acids and proteins between distant organs, the interaction of their surface proteins with target cells, and the role of vesicle-bound lipids in health and disease. To date, most observations have been made in reductionist cell culture systems, or as snapshots from patient cohorts. The heterogenous population of vesicles produced in vivo likely act in concert to mediate both beneficial and detrimental effects. EVs play crucial roles in both the pathogenesis of diseases, from cancer to neurodegenerative disease, as well as in the maintenance of system and organ homeostasis. This two-part review draws on the expertise of researchers working in the field of EV biology and aims to cover the functional role of EVs in physiology and pathology. Part I will outline the role of EVs in normal physiology. (AU)

FAPESP's process: 11/09172-3 - Evaluation of circulating microparticles derived from invasive ductal breast adenocarcinomas Her2+ patients and it's possible correlation with tumor aggressiveness
Grantee:Emmanuel Dias-Neto
Support Opportunities: Regular Research Grants
FAPESP's process: 15/50257-3 - Extracellular vesicles and non-cellular RNA: roles in health and neglected tropical diseases | São Paulo - SP
Grantee:Emmanuel Dias-Neto
Support Opportunities: Organization Grants - Scientific Meeting
FAPESP's process: 14/26897-0 - Epidemiology and genomics of gastric adenocarcinomas in Brazil
Grantee:Emmanuel Dias-Neto
Support Opportunities: Research Projects - Thematic Grants