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(Reference retrieved automatically from Web of Science through information on FAPESP grant and its corresponding number as mentioned in the publication by the authors.)

lebsiella-induced infections in domestic species: a case-series study in 697 animals (1997-2019

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Ribeiro, Marcio Garcia [1, 2] ; Cordeiro de Morais, Amanda Bonalume [2] ; Alves, Ana Carolina [2] ; Daza Bolanos, Carmen Alicia [3] ; de Paula, Carolina Lechinski [2] ; Ramos Portilho, Fabio Vinicius [2] ; de Nardi Junior, Geraldo [4] ; Batista Lara, Gustavo Henrique [2] ; Araujo Martins, Lorrayne de Souza [2] ; Moraes, Lucieny Sierra [2] ; Risseti, Rafaela Mastrangelo [2] ; Guerra, Simony Trevizan [2] ; Bello, Thais Spessotto [2] ; Siqueira, Amanda Keller [2] ; Bertolini, Amanda Bezerra [2] ; Rodrigues, Carolina Aparecida [2] ; Paschoal, Natalia Rodrigues [2] ; de Almeida, Beatriz Oliveira [2] ; Paganini Listoni, Fernando Jose [2] ; Garcia Sanchez, Luisa Fernanda [2] ; Paes, Antonio Carlos [2]
Total Authors: 21
Affiliation:
[1] Sao Paulo State Univ UNESP, Sch Vet Med & Anim Sci, BR-18618681 Botucatu, SP - Brazil
[2] Sao Paulo State Univ UNESP, Dept Anim Prod & Prevent Vet Med, Botucatu, SP - Brazil
[3] Antonio Narino Univ, Fac Vet Med & Anim Sci, Dept Vet Med, Bogota - Colombia
[4] FATEC, Technol Fac, Botucatu, SP - Brazil
Total Affiliations: 4
Document type: Journal article
Source: Brazilian Journal of Microbiology; v. 53, n. 1 JAN 2022.
Web of Science Citations: 0
Abstract

Klebsiella species, particularly K. pneumoniae, are well-known opportunistic enterobacteria related to complexity of clinical infections in humans and animals, commonly refractory to conventional therapy. The domestic animals may represent a source of the pathogenic and multidrug-resistant Klebsiella species to humans. Nevertheless, most studies involving Klebsiella-induced infections in domestic animals are restricted to case reports or outbreaks. We retrospectively investigated selected epidemiological data, clinical aspects, and in vitro susceptibility pattern of 697 non-repetitive Klebsiella infections in livestock and companion species (1997-2019). The isolates were obtained from different clinical disorders from dogs (n=393), cattle (n = 149), horses (n = 98), cats (n = 27), pigs (n= 22), sheep (n = 5), goats (n = 2), and buffalo (n =1), except four isolates from subclinical bovine mastitis. Urinary (223/697 = 32%), enteric (117/697 = 16.8%), mammary (85/697 =12.2%), reproductive (85/697 =12.2%), and respiratory disorders (67/697 = 9.6%) were the most common clinical manifestations. Other miscellaneous clinical pictures (116/697 =16.6%) included abscesses, otitis, hepatitis, conjunctivitis, pyodermitis, sepsis, and encephalitis. Norfloxacin (183/245 =74.7%) and gentamicin (226/330 = 68.5%) were the most effective antimicrobials. High in vitro resistance of the isolates was seen to ampicillin (326/355 = 91.8%), amoxicillin/clavulanic acid (25/62=40.3%), and trimethoprim/sulfamethoxazole (100/252 =39.7), and multidrug resistance to >= 3 classes of antimicrobials was found in 20.4% (142/697) isolates. Wide variety of clinical manifestations of Klebsiella-induced infections was observed, with a predominance of urinary, enteric, mammary, reproductive, and respiratory tract disorders, reinforcing opportunistic behavior of agent. Poor in vitro efficacy was observed to some conventional antimicrobials and similar to 20% of isolates exhibited resistance pattern, reinforcing the need for proper use of drugs on therapy approaches in domestic animals to avoid multidrug-resistant bacteria, an emergent global concern. (AU)

FAPESP's process: 15/19688-8 - E. coli, Klebsiella pnemoniae and Enterococcus spp: impact of virulence factors in bovine mastitis and public health concern
Grantee:Helio Langoni
Support Opportunities: Research Projects - Thematic Grants