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(Reference retrieved automatically from Web of Science through information on FAPESP grant and its corresponding number as mentioned in the publication by the authors.)

Respiratory disorders of Parkinson's disease

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Aquino, Yasmin C. [1] ; Cabral, Lais M. [1] ; Miranda, Nicole C. [1] ; Naccarato, Monique C. [1] ; Falquetto, Barbara [1] ; Moreira, Thiago S. [2] ; Takakura, Ana C. [1]
Total Authors: 7
[1] Univ Sao Paulo, Inst Ciencias Biomed, Dept Pharmacol, Sao Paulo - Brazil
[2] Univ Sao Paulo, Inst Ciencias Biomed, Dept Physiol & Biophys, Sao Paulo - Brazil
Total Affiliations: 2
Document type: Review article
Source: Journal of Neurophysiology; v. 127, n. 1, p. 1-15, JAN 2022.
Web of Science Citations: 0

Parkinson's disease (PD) is characterized by the progressive loss of dopaminergic neurons in the substantia nigra, mainly affecting people over 60 yr of age. Patients develop both classic symptoms (tremors, muscle rigidity, bradykinesia, and postural instability) and nonclassical symptoms (orthostatic hypotension, neuropsychiatric deficiency, sleep disturbances, and respiratory disorders). Thus, patients with PD can have a significantly impaired quality of life, especially when they do not have multimodality therapeutic follow-up. The respiratory alterations associated with this syndrome are the main cause of mortality in PD. They can be classified as peripheral when caused by disorders of the upper airways or muscles involved in breathing and as central when triggered by functional deficits of important neurons located in the brainstem involved in respiratory control. Currently, there is little research describing these disorders, and therefore, there is no well-established knowledge about the subject, making the treatment of patients with respiratory symptoms difficult. In this review, the history of the pathology and data about the respiratory changes in PD obtained thus far will be addressed. (AU)

FAPESP's process: 15/23376-1 - Retrotrapezoid nucleus, respiratory chemosensitivity and breathing automaticity
Grantee:Thiago dos Santos Moreira
Support type: Research Projects - Thematic Grants
FAPESP's process: 20/16320-8 - Investigation of the existence of anatomical projections from substantia nigra to pre-Bötzinger complex
Grantee:Yasmin Cestari Aquino
Support type: Scholarships in Brazil - Scientific Initiation
FAPESP's process: 19/00065-1 - Oxidative stress in respiratory control of Parkinson Disease animal model
Grantee:Bárbara Falquetto
Support type: Research Grants - Young Investigators Grants
FAPESP's process: 19/01236-4 - Effects of pharmacological and non-pharmacological treatments on respiratory changes observed in a murine model of Parkinson's disease
Grantee:Ana Carolina Thomaz Takakura
Support type: Regular Research Grants