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(Reference retrieved automatically from Web of Science through information on FAPESP grant and its corresponding number as mentioned in the publication by the authors.)

Interacting Epidemics in Amazonian Brazil: Prior Dengue Infection Associated With Increased Coronavirus Disease 2019 (COVID-19) Risk in a Population-Based Cohort Stud

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Author(s):
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Nicolete, Vanessa C. [1] ; Rodrigues, Priscila T. [1] ; Johansen, Igor C. [1] ; Corder, Rodrigo M. [1] ; Tonini, Juliana [1] ; Cardoso, Marly A. [2] ; de Jesus, Jaqueline G. [3, 4] ; Claro, Ingra M. [3, 4] ; Faria, Nuno R. [5, 6, 3, 4] ; Sabino, Ester C. [3, 4] ; Castro, Marcia C. [7] ; Ferreira, Marcelo U. [1]
Total Authors: 12
Affiliation:
[1] Univ Sao Paulo, Inst Biomed Sci, Dept Parasitol, Sao Paulo - Brazil
[2] Univ Sao Paulo, Sch Publ Hlth, Dept Nutr, Sao Paulo - Brazil
[3] Univ Sao Paulo, Med Sch, Inst Trop Med, Sao Paulo - Brazil
[4] Univ Sao Paulo, Med Sch, Dept Infect & Parasit Dis, Sao Paulo - Brazil
[5] Univ Oxford, Dept Zool, Oxford - England
[6] Imperial Coll London, Dept Infect Dis Epidemiol, London - England
[7] Harvard TH Chan Sch Publ Hlth, Dept Global Hlth & Populat, Boston, MA - USA
Total Affiliations: 7
Document type: Journal article
Source: Clinical Infectious Diseases; v. 73, n. 11, p. 2045-2054, DEC 1 2021.
Web of Science Citations: 4
Abstract

Background. Immunity after dengue virus (DENV) infection has been suggested to cross-protect from severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection and mortality. Methods. We tested whether serologically proven prior DENV infection diagnosed in September-October 2019, before the coronavirus disease 2019 (COVID-19) pandemic, reduced the risk of SARS-CoV-2 infection and clinically apparent COVID-19 over the next 13 months in a population-based cohort in Amazonian Brazil. Mixed-effects multiple logistic regression analysis was used to identify predictors of infection and disease, adjusting for potential individual and household-level confounders. Virus genomes from 14 local SARS-CoV-2 isolates were obtained using whole-genome sequencing. Results. Anti-DENV immunoglobulin G (IgG) was found in 37.0% of 1285 cohort participants (95% confidence interval {[}CI]: 34.3% to 39.7%) in 2019, with 10.4 (95% CI: 6.7-15.5) seroconversion events per 100 person-years during the follow-up. In 2020, 35.2% of the participants (95% CI: 32.6% to 37.8%) had anti-SARS-CoV-2 IgG and 57.1% of the 448 SARS-CoV-2 seropositives (95% CI: 52.4% to 61.8%) reported clinical manifestations at the time of infection. Participants aged >60 years were twice more likely to have symptomatic COVID-19 than children under 5 years. Locally circulating SARS-CoV-2 isolates were assigned to the B.1.1.33 lineage. Contrary to the cross-protection hypothesis, prior DENV infection was associated with twice the risk of clinically apparent COVID-19 upon SARS-CoV-2 infection, with P values between .025 and .039 after adjustment for identified confounders. Conclusions. Higher risk of clinically apparent COVID-19 among individuals with prior dengue has important public health implications for communities sequentially exposed to DENV and SARS-CoV-2 epidemics. (AU)

FAPESP's process: 18/14389-0 - Brazil-UK Centre for Arbovirus Discovery, Diagnosis, Genomics and Epidemiology (CADDE)
Grantee:Ester Cerdeira Sabino
Support type: Research Projects - Thematic Grants
FAPESP's process: 20/04505-3 - Tracking the community-wide spread of SARS-CoV-2: outbreak size, transmission dynamics, clinical outcomes of infection, and duration of naturally acquired antibody responses in an Amazonian town
Grantee:Marcelo Urbano Ferreira
Support type: Regular Research Grants
FAPESP's process: 16/18740-9 - Scientific bases for residual malaria elimination in the Brazilian Amazon
Grantee:Marcelo Urbano Ferreira
Support type: Research Projects - Thematic Grants