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(Reference retrieved automatically from Web of Science through information on FAPESP grant and its corresponding number as mentioned in the publication by the authors.)

Role of Iron Phthalocyanine Coordination in Catecholamines Detection

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Martin, Cibely S. [1] ; Rubira, Rafael J. G. [1] ; Silva, Jaqueline N. [1] ; Alessio, Priscila [1]
Total Authors: 4
[1] Sao Paulo State Univ UNESP, Sch Technol & Appl Sci, BR-19060080 Presidente Prudente, SP - Brazil
Total Affiliations: 1
Document type: Journal article
Source: SURFACES; v. 4, n. 4, p. 323-335, DEC 2021.
Web of Science Citations: 0

Catecholamines are an important class of neurotransmitters responsible for regularizing, controlling, and treating neural diseases. Based on control and diseases treatment, the development of methodology and dives to sensing is a promissory technology area. This work evaluated the role of iron phthalocyanine coordination (FePc) with the specific groups from catecholamine molecules (L-dopa, dopamine, epinephrine, and the amino acid tyrosine) and the effect of this coordination on electrochemical behavior. The in situ coordination analysis was performed through isotherms pi-A of FePc Langmuir films in the absence and presence of catecholamines. The pi-A isotherm indicates a strong interaction between FePc monolayer and L-Dopa and DA, which present a catechol group and a side chain with a protonated amino group (-NH3+). These strong interactions with catechol and amine groups were confirmed by characterization at the molecular level using the surface-enhanced Raman spectroscopy (SERS) from a Langmuir-Schaefer monolayer deposited onto Ag surfaces. The electrochemical measurements present a similar tendency, with lower oxidation potential observed to DA>L-Dopa>Ep. The results corroborate that the coordination of the analyte on the electron mediator surface plays an essential role in an electrochemical sensing application. The FePc LS film was applied as a sensor in tablet drug samples, showing a uniformity of content of 96% for detecting active compounds present in the L-Dopa drug samples. (AU)

FAPESP's process: 17/15019-0 - Combination of confocal fluorescence microscopy and surface-enhanced Raman scattering techniques: interaction, detection, and quantification of molecules of interest in biomimetic system.
Grantee:Cibely da Silva Martin Sonvesso
Support Opportunities: Scholarships in Brazil - Post-Doctoral
FAPESP's process: 14/50869-6 - INCT 2014: on Organic Electronics
Grantee:Roberto Mendonça Faria
Support Opportunities: Research Projects - Thematic Grants
FAPESP's process: 17/06534-8 - Impact of Emerging Pollutants in Health: a Study on Biomimetic Membranes
Grantee:Priscila Alessio Constantino
Support Opportunities: Regular Research Grants
FAPESP's process: 20/05423-0 - Detection of pesticides (cocktails) used in sugarcane crops and their effect on biological systems
Grantee:Rafael Jesus Gonçalves Rubira
Support Opportunities: Scholarships in Brazil - Post-Doctoral