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(Reference retrieved automatically from Web of Science through information on FAPESP grant and its corresponding number as mentioned in the publication by the authors.)

Protein markers of spermatogenesis and their potential use in the management of azoospermia

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Araujo, Sophia Costa [1] ; Bertolla, Ricardo Pimenta [1]
Total Authors: 2
[1] Univ Fed Sao Paulo, Div Urol, Human Reprod Sect, Dept Surg, Sao Paulo - Brazil
Total Affiliations: 1
Document type: Review article
Source: EXPERT REVIEW OF PROTEOMICS; v. 18, n. 11, p. 939-948, NOV 2 2021.
Web of Science Citations: 0

Introduction Azoospermia, absence of sperm in the ejaculate is classified as obstructive (OA) and non-obstructive azoospermia (NOA). In OA, sperm are produced, but due to physical obstruction in the male reproductive tract, they are not released in the ejaculate. NOA, on the other hand, is defined as the absence of sperm in the ejaculate due to testicular dysfunction. In NOA, spermatogenesis is frequently preserved in specific sites, and proteomics studies have been employed in order to identify men with preserved spermatogenesis. Areas covered Differential protein expression in patients with male infertility is an indicator of impaired spermatogenesis. Here, we reviewed proteins with a potential role as biomarkers of spermatogenesis that could help in the management of non-obstructive and obstructive azoospermia. The following keywords were used for bibliographic research: seminal plasma, proteomics, male infertility, nonobstructive, obstructive, azoospermia, oligospermia. Expert opinion Biopsy is an invasive and potentially harmful technique for detecting spermatogenesis in men with OA and NOA. Seminal plasma proteins are highly promising as biomarkers for spermatogenesis. Current literature presents a number of potential candidate biomarkers for determining preserved spermatogenesis. (AU)

FAPESP's process: 19/09970-9 - Molecular characterization of seminal extracellular vesicles, spermatozoa and seminal plasma in varicocele and its association with seminal inflammatory aspects
Grantee:Ricardo Pimenta Bertolla
Support Opportunities: Regular Research Grants