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(Reference retrieved automatically from Web of Science through information on FAPESP grant and its corresponding number as mentioned in the publication by the authors.)

Polycaprolactone usage in additive manufacturing strategies for tissue engineering applications: A review

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Backes, Eduardo Henrique [1] ; Harb, Samarah Vargas [1] ; Beatrice, Cesar Augusto Goncalves [1] ; Shimomura, Kawany Munique Boriolo [1] ; Passador, Fabio Roberto [2] ; Costa, Lidiane Cristina [1] ; Pessan, Luiz Antonio [1]
Total Authors: 7
[1] Univ Fed Sao Carlos, Dept Mat Engn, Grad Program Mat Sci & Engn, Rodovia Washington Luiz, Km 235, BR-13565905 Sao Carlos - Brazil
[2] Univ Fed Sao Paulo, Inst Sci & Technol, Sao Paulo - Brazil
Total Affiliations: 2
Document type: Review article
Web of Science Citations: 0

Polycaprolactone (PCL) has been extensively applied on tissue engineering because of its low-melting temperature, good processability, biodegradability, biocompatibility, mechanical resistance, and relatively low cost. The advance of additive manufacturing (AM) technologies in the past decade have boosted the fabrication of customized PCL products, with shorter processing time and absence of material waste. In this context, this review focuses on the use of AM techniques to produce PCL scaffolds for various tissue engineering applications, including bone, muscle, cartilage, skin, and cardiovascular tissue regeneration. The search for optimized geometry, porosity, interconnectivity, controlled degradation rate, and tailored mechanical properties are explored as a tool for enhancing PCL biocompatibility and bioactivity. In addition, rheological and thermal behavior is discussed in terms of filament and scaffold production. Finally, a roadmap for future research is outlined, including the combination of PCL struts with cell-laden hydrogels and 4D printing. (AU)

FAPESP's process: 18/14151-4 - Development and characterization of bioactive PCL/TCP composites
Grantee:Kawany Munique Boriolo Shimomura
Support type: Scholarships in Brazil - Scientific Initiation
FAPESP's process: 17/11366-7 - Development of bio-inspired PLA/bioglass scaffolds via 3D printed
Grantee:Eduardo Henrique Backes
Support type: Scholarships in Brazil - Doctorate
FAPESP's process: 18/26060-3 - Bioactive and bactericidal scaffolds for bone regeneration via 3D printing
Grantee:Samarah Vargas Harb
Support type: Scholarships in Brazil - Post-Doctorate
FAPESP's process: 17/09609-9 - Development of bioinspired scaffolds of PLA/bioactive ceramic fillers through 3D printing
Grantee:Luiz Antonio Pessan
Support type: Regular Research Grants