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(Reference retrieved automatically from Web of Science through information on FAPESP grant and its corresponding number as mentioned in the publication by the authors.)

Healthy and Chronic Kidney Disease (CKD) Dogs Have Differences in Serum Metabolomics and Renal Diet May Have Slowed Disease Progression

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Brunetto, Marcio Antonio [1, 2] ; Ruberti, Bruna [3] ; Halfen, Doris Pereira [2] ; Caragelasco, Douglas Segalla [3] ; Vendramini, Thiago Henrique Annibale [1] ; Pedrinelli, Vivian [2] ; Macedo, Henrique Tobaro [1] ; Jeremias, Juliana Toloi [4] ; Pontieri, Cristiana Fonseca Ferreira [4] ; Ocampos, Fernanda Maria Marins [5] ; Colnago, Luis Alberto [5] ; Kogika, Marcia Mery [3]
Total Authors: 12
[1] Univ Sao Paulo, Sch Vet Med & Anim Sci, Nutr & Prod Dept, Pet Nutrol Res Ctr, BR-13635900 Pirassununga - Brazil
[2] Univ Sao Paulo, Vet Teaching Hosp, Sch Vet Med & Anim Sci, Vet Nutrol Serv, Cidade Univ, BR-05508270 Sao Paulo - Brazil
[3] Univ Sao Paulo, Vet Teaching Hosp, Sch Vet Med & Anim Sci, Small Anim Internal Med Serv, Cidade Univ, BR-05508270 Sao Paulo - Brazil
[4] Nutr Dev Ctr, Grandfood Ind Comercio LTDA Premier Pet R, BR-05508270 Sao Paulo - Brazil
[5] Embrapa Instrumentacao, R 15 Novembro 1452 Ctr, BR-13560970 Sao Carlos - Brazil
Total Affiliations: 5
Document type: Journal article
Source: METABOLITES; v. 11, n. 11 NOV 2021.
Web of Science Citations: 0

Chronic kidney disease (CKD) is highly prevalent in dogs, and metabolomics investigation has been recently introduced for a better understanding of the role of diet in CKD. This study aimed to compare the serum metabolomic profile of healthy dogs (CG) and dogs with CKD (CKD-T0 and CKD-T6) to evaluate whether the diet would affect metabolites. Six dogs (5 females; 1 male; 7.47 \& PLUSMN; 2.31 years old) with CKD stage 3 or 4 (IRIS) were included. CG consisted of 10 healthy female dogs (5.89 \& PLUSMN; 2.57 years old) fed a maintenance diet. Serum metabolites were analyzed by H-1 nuclear magnetic resonance (H-1 NMR) spectra. Principal component analysis (PCA) and partial least squares discriminant analysis (PLS-DA) were performed to assess differences in metabolomic profiles between groups and before (CKD-T0) and after renal diet (CKD-T6). Data analysis was performed on SIMCA-P software. Dogs with CKD showed an altered metabolic profile with increased urea, creatinine, creatine, citrate, and lipids. Lactate, branched-chain amino acids (BCAAs), and glutamine were decreased in the CKD group. However, after 6 months of diet, the metabolite profiles of CKD-T0 and CKD-T6 were similar. Metabolomics profile may be useful to evaluate and recognize metabolic dysfunction and progression of CKD, and the diet may have helped maintain and retard the progression of CKD. (AU)

FAPESP's process: 18/00504-2 - NMR-based metabolomic investigation of potential natural agrochemicals from Schiekia orinocensis under biotic and abiotic stress
Grantee:Fernanda Maria Marins Ocampos Facure
Support Opportunities: Scholarships in Brazil - Post-Doctoral