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(Reference retrieved automatically from Web of Science through information on FAPESP grant and its corresponding number as mentioned in the publication by the authors.)

Antineoplastics Encapsulated in Nanostructured Lipid Carriers

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Rodrigues da Silva, Gustavo Henrique [1] ; de Moura, Ludmilla David [1] ; de Carvalho, Fabiola Vieira [1] ; Geronimo, Gabriela [1] ; Mendonca, Talita Cesarim [1] ; de Lima, Fernando Freitas [1] ; de Paula, Eneida [1]
Total Authors: 7
[1] Univ Estadual Campinas, UNICAMP, Inst Biol, Dept Biochem & Tissue Biol, BR-13083862 Campinas - Brazil
Total Affiliations: 1
Document type: Review article
Source: Molecules; v. 26, n. 22 NOV 2021.
Web of Science Citations: 0

Ideally, antineoplastic treatment aims to selectively eradicate cancer cells without causing systemic toxicity. A great number of antineoplastic agents (AAs) are available nowadays, with well-defined therapeutic protocols. The poor bioavailability, non-selective action, high systemic toxicity, and lack of effectiveness of most AAs have stimulated the search for novel chemotherapy protocols, including technological approaches that provide drug delivery systems (DDS) for gold standard medicines. Nanostructured lipid carriers (NLC) are DDS that contain a core of solid and lipid liquids stabilised by surfactants. NLC have high upload capacity for lipophilic drugs, such as the majority of AAs. These nanoparticles can be prepared with a diversity of biocompatible (synthetic or natural) lipid blends, administered by different routes and functionalised for targeting purposes. This review focused on the research carried out from 2000 to now, regarding NLC formulations for AAs (antimetabolites, antimitotics, alkylating agents, and antibiotics) encapsulation, with special emphasis on studies carried out in vivo. NLC systems for codelivery of AAs were also considered, as well as those for non-classical drugs and therapies (natural products and photosensitisers). NLC have emerged as powerful DDS to improve the bioavailability, targeting and efficacy of antineoplastics, while decreasing their toxic effect in the treatment of different types of cancer. (AU)

FAPESP's process: 19/17784-0 - Plasma pharmacokinetics and tissue biodistribution of lipid-based nanoformulations
Grantee:Eneida de Paula
Support type: Regular Research Grants
FAPESP's process: 21/02617-1 - Photodynamic therapy with chlorine-aluminum phalocyanine in nano-structured lipid carriers containing doxorrubicin to treat breast cancer
Grantee:Talita Cesarim Mendonça
Support type: Scholarships in Brazil - Master
Grantee:Fernando Freitas de Lima
Support type: Scholarships in Brazil - Post-Doctorate
FAPESP's process: 20/01237-8 - Encapsulation of bioactive and probiotic components by combined method for the development of functional drinks based on fruits and whey
Grantee:Fernando Freitas de Lima
Support type: Scholarships in Brazil - Post-Doctorate
FAPESP's process: 17/15174-5 - Development of functional lipid nanoparticles for the improvement of the anesthetic potency at inflamed tissues
Grantee:Gustavo Henrique Rodrigues da Silva
Support type: Scholarships in Brazil - Doctorate