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(Reference retrieved automatically from Web of Science through information on FAPESP grant and its corresponding number as mentioned in the publication by the authors.)

lusters of SARS-CoV-2 Lineage B.1.1.7 Infection after Vaccination with Adenovirus-Vectored and Inactivated Vaccine

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Author(s):
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de Souza, William M. [1, 2] ; Muraro, Stefanie P. [3] ; Souza, Gabriela F. [3] ; Amorim, Mariene R. [3] ; Sesti-Costa, Renata [4, 5] ; Mofatto, Luciana S. [3] ; Forato, Julia [3] ; Barbosa, Priscilla P. [3] ; Toledo-Teixeira, Daniel A. [3] ; Bispo-dos-Santos, Karina [3] ; Parise, Pierina L. [3] ; Brunetti, Natalia S. [6] ; Moreira, Joselia C. O. [7] ; Costa, Vitor A. [5] ; Cardozo, Daniela M. [8] ; Moretti, Maria L. [9] ; Barros-Mazon, Silvia [8] ; Marchesi, Gabriela F. [10] ; Ambrosio, Christiane [10] ; Spilki, Fernando R. [11] ; Almeida, Valeria C. [10] ; Vieira, Andre S. [7] ; Zambon, Lair [9] ; Farias, Alessandro S. [12, 13] ; Addas-Carvalho, Marcelo [5] ; Benites, Bruno D. [5] ; Marques, Rafael E. [4] ; Sabino, Ester C. [14, 15] ; Von Zuben, Andrea B. ; Weaver, Scott C. [16, 1] ; Faria, Nuno R. [17, 14, 18] ; Granja, Fabiana [19] ; Angerami, Rodrigo N. [9, 10] ; Proenca-Modena, Jose Luiz [13, 3]
Total Authors: 34
Affiliation:
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[1] Univ Texas Med Branch, Dept Microbiol & Immunol, Galveston, TX 77555 - USA
[2] Univ Sao Paulo, Ribeirao Preto Med Sch, Virol Res Ctr, BR-14049900 Ribeirao Preto - Brazil
[3] Univ Estadual Campinas, Inst Biol, Dept Genet, Lab Emerging Viruses, BR-13083862 Campinas - Brazil
[4] Brazilian Ctr Res Energy & Mat, Brazilian Biosci Natl Lab, BR-13083100 Campinas - Brazil
[5] Univ Estadual Campinas, Hematol & Hemotherapy Ctr, BR-13083862 Campinas - Brazil
[6] Univ Estadual Campinas, Inst Biol, Dept Genet, Autoimmune Res Lab, BR-13083862 Campinas - Brazil
[7] Univ Estadual Campinas, Inst Biol, Dept Struct & Funct Biol, BR-13083862 Campinas - Brazil
[8] Univ Estadual Campinas, Sch Med Sci, Dept Clin Pathol, BR-13083862 Campinas - Brazil
[9] Univ Estadual Campinas, Sch Med Sci, Dept Internal Med, BR-13083862 Campinas - Brazil
[10] Campinas Dept Publ Hlth Surveillance, BR-13015904 Campinas - Brazil
[11] Feevale Univ, One Hlth Lab, BR-93510235 Novo Hamburgo - Brazil
[12] Univ Estadual Campinas, Obes & Comorbid Res Ctr, BR-13083862 Campinas - Brazil
[13] Univ Estadual Campinas, Expt Med Res Cluster, BR-13083862 Campinas - Brazil
[14] Univ Sao Paulo, Sch Med, Dept Infect & Parasit Dis, BR-05403000 Sao Paulo - Brazil
[15] Univ Sao Paulo, Inst Trop Med, Sch Med, BR-05403907 Sao Paulo - Brazil
[16] Univ Texas Med Branch, Inst Human Infect & Immun, Galveston, TX 77555 - USA
[17] Univ Oxford, Dept Zool, Oxford OX1 2JD - England
[18] Imperial Coll London, MRC Ctr Global Infect Dis Anal, J IDEA, London SW7 2AZ - England
[19] Univ Fed Roraima, Biodivers Res Ctr, BR-72000000 Boa Vista, Parana - Brazil
Total Affiliations: 19
Document type: Journal article
Source: Viruses-Basel; v. 13, n. 11 NOV 2021.
Web of Science Citations: 1
Abstract

A SARS-CoV-2 B.1.1.7 variant of concern (VOC) has been associated with increased transmissibility, hospitalization, and mortality. This study aimed to explore the factors associated with B.1.1.7 VOC infection in the context of vaccination. On March 2021, we detected SARS-CoV-2 RNA in nasopharyngeal samples from 14 of 22 individuals vaccinated with a single-dose of ChAdOx1 (outbreak A, n = 26), and 22 of 42 of individuals with two doses of the CoronaVac vaccine (outbreak B, n = 52) for breakthrough infection rates for ChAdOx1 of 63.6% and 52.4% for CoronaVac. The outbreaks were caused by two independent clusters of the B.1.1.7 VOC. The serum of PCR-positive symptomatic SARS-CoV-2-infected individuals had \~{}1.8-3.4-fold more neutralizing capacity against B.1.1.7 compared to the serum of asymptomatic individuals. These data based on exploratory analysis suggest that the B.1.1.7 variant can infect individuals partially immunized with a single dose of an adenovirus-vectored vaccine or fully immunized with two doses of an inactivated vaccine, although the vaccines were able to reduce the risk of severe disease and death caused by this VOC, even in the elderly. (AU)

FAPESP's process: 16/00194-8 - Pathogenesis and neurovirulence of emerging viruses in Brazil
Grantee:José Luiz Proença Módena
Support Opportunities: Research Grants - Young Investigators Grants
FAPESP's process: 18/14389-0 - Brazil-UK Centre for Arbovirus Discovery, Diagnosis, Genomics and Epidemiology (CADDE)
Grantee:Ester Cerdeira Sabino
Support Opportunities: Research Projects - Thematic Grants
FAPESP's process: 18/13645-3 - The role of innate recognition pathways and type I and III interferons in the rupture of the placental barrier after OROV infection
Grantee:Stefanie Primon Muraro
Support Opportunities: Scholarships in Brazil - Doctorate
FAPESP's process: 17/26908-0 - The role of IRF-5 in Oropouche virus pathogenesis and neurovirulence
Grantee:Pierina Lorencini Parise
Support Opportunities: Scholarships in Brazil - Doctorate (Direct)
FAPESP's process: 20/02159-0 - Antiviral activity of AAK1 inhibitors against Oropouche infection
Grantee:Karina Bispo dos Santos
Support Opportunities: Scholarships in Brazil - Master
FAPESP's process: 17/13981-0 - Characterization, genomics and diagnostic of viruses with importance for public health in Brazil by high throughput sequencing
Grantee:William Marciel de Souza
Support Opportunities: Scholarships in Brazil - Post-Doctoral
FAPESP's process: 19/09704-7 - Dendritic cells in Sickle Cell Anemia: molecular mechanisms involved in regulating inflammation and adaptive immune response
Grantee:Renata Sesti Costa
Support Opportunities: Research Grants - Young Investigators Grants
FAPESP's process: 18/10224-7 - The role of activation and metabolic imbalance of dendritic cells for Chikungunya virus pathogenesis
Grantee:Gabriela Fabiano de Souza
Support Opportunities: Scholarships in Brazil - Doctorate
FAPESP's process: 19/24251-9 - Multi-omic approaches for the study of Chikungunya disease
Grantee:William Marciel de Souza
Support Opportunities: Scholarships abroad - Research Internship - Post-doctor
FAPESP's process: 20/04558-0 - Characterization of intrinsic risk factors and the development of new diagnostic and treatment alternatives for COVID-19
Grantee:José Luiz Proença Módena
Support Opportunities: Regular Research Grants