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(Reference retrieved automatically from Web of Science through information on FAPESP grant and its corresponding number as mentioned in the publication by the authors.)

hree-dimensional cell-laden collagen scaffolds: From biochemistry to bone bioengineerin

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Author(s):
Nogueira, Lucas Fabricio Bahia [1, 2] ; Maniglia, Bianca C. [2] ; Buchet, Rene [3] ; Millan, Jose Luis [4] ; Ciancaglini, Pietro [2] ; Bottini, Massimo [4, 1] ; Ramos, Ana Paula [2]
Total Authors: 7
Affiliation:
[1] Univ Roma Tor Vergata, Dept Expt Med, I-00133 Rome - Italy
[2] Univ Sao Paulo FFCLRP USP, Dept Quim, Fac Filosofia, Ciencias Letras Ribeirao Preto, Sao Paulo - Brazil
[3] Univ Claude Bernard Lyon 1, Inst Mol & Supramol Chem & Biochem, Villeurbanne - France
[4] Sanford Childrens Hlth Res Ctr, Sanford Burnham Prebys Med Discovery Inst, La Jolla, CA - USA
Total Affiliations: 4
Document type: Review article
Source: JOURNAL OF BIOMEDICAL MATERIALS RESEARCH PART B-APPLIED BIOMATERIALS; v. 110, n. 4 NOV 2021.
Web of Science Citations: 0
Abstract

The bones can be viewed as both an organ and a material. As an organ, the bones give structure to the body, facilitate skeletal movement, and provide protection to internal organs. As a material, the bones consist of a hybrid organic/inorganic three-dimensional (3D) matrix, composed mainly of collagen, noncollagenous proteins, and a calcium phosphate mineral phase, which is formed and regulated by the orchestrated action of a complex array of cells including chondrocytes, osteoblasts, osteocytes, and osteoclasts. The interactions between cells, proteins, and minerals are essential for the bone functions under physiological loading conditions, trauma, and fractures. The organization of the bone's organic and inorganic phases stands out for its mechanical and biological properties and has inspired materials research. The objective of this review is to fill the gaps between the physical and biological characteristics that must be achieved to fabricate scaffolds for bone tissue engineering with enhanced performance. We describe the organization of bone tissue highlighting the characteristics that have inspired the development of 3D cell-laden collagenous scaffolds aimed at replicating the mechanical and biological properties of bone after implantation. The role of noncollagenous macromolecules in the organization of the collagenous matrix and mineralization ability of entrapped cells has also been reviewed. Understanding the modulation of cell activity by the extracellular matrix will ultimately help to improve the biological performance of 3D cell-laden collagenous scaffolds used for bone regeneration and repair as well as for in vitro studies aimed at unravelling physiological and pathological processes occurring in the bone. (AU)

FAPESP's process: 19/08568-2 - Investigation of the extracellular vesicles (VEs) role in the initiation, propagation, regeneration, and modeling of biological mineralization
Grantee:Pietro Ciancaglini
Support type: Research Projects - Thematic Grants
FAPESP's process: 20/08727-0 - Starch modification by green methods for elaboration via 3D printing of bone scaffolds activated by the presence of hydroxyapatite nanoparticles replaced by Sr2+
Grantee:Bianca Chieregato Maniglia
Support type: Research Grants - Young Investigators Grants
FAPESP's process: 19/25054-2 - Strontium-containing nanoparticles and their versatility for biomaterials fabrication: implications and applications in biomineralization
Grantee:Ana Paula Ramos
Support type: Regular Research Grants
FAPESP's process: 18/25871-8 - Scaffolds composed by bioactive glasses and injectable matrices for bone regeneration
Grantee:Lucas Fabrício Bahia Nogueira
Support type: Scholarships in Brazil - Doctorate