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(Reference retrieved automatically from Web of Science through information on FAPESP grant and its corresponding number as mentioned in the publication by the authors.)

Astrocytes as essential time-keepers of the central pacemaker

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Author(s):
Astiz, Mariana [1] ; Delgado-Garcia, Lina Maria [2] ; Lopez-Mascaraque, Laura [3]
Total Authors: 3
Affiliation:
[1] Univ Lubeck, Ctr Brain Behav & Metab CBBM, Inst Neurobiol, Marie Curie Str, D-23562 Lubeck - Germany
[2] Univ Fed Sao Paulo, UNIFESP, Dept Biochem, Sao Paulo - Brazil
[3] CSIC, Inst Cajal, Madrid - Spain
Total Affiliations: 3
Document type: Review article
Source: Glia; NOV 2021.
Web of Science Citations: 0
Abstract

Since the early observations made by Santiago Ramon y Cajal more than a century ago till now, astrocytes have gradually gained protagonism as essential partners of neurons in building brain circuits that regulate complex behavior. In mammals, processes such as sleep-wake cycle, locomotor activity, cognition and memory consolidation, homeostatic and hedonic appetite and stress response (among others), are synchronized in 24-h rhythms by the circadian system. In such a way, physiology efficiently anticipates and adapts to daily recurring changes in the environment. The hypothalamic suprachiasmatic nucleus (SCN) is considered the central pacemaker, it has been traditionally described as a nucleus of around 10,000 neurons nearly all GABAergic able to be entrained by light and to convey time information through multiple neuronal and hormonal pathways. Only recently, this neuro-centered view was challenged by breakthrough discoveries implicating astrocytes as essential time-keepers. In the present review, we will describe the current view on the SCN circuit and discuss whether astrocytic functions described in other brain regions and state-of-the-art experimental approaches, could help explaining better those well- and not so well-known features of the central pacemaker. (AU)

FAPESP's process: 16/19084-8 - Crosstalk among Wnt, SHH and Notch and the efect of Gal3 protein on the regulation of the proliferation of derived-neural stem cells reactive astrocytes
Grantee:Lina Maria Delgado Garcia
Support Opportunities: Scholarships in Brazil - Doctorate
FAPESP's process: 19/09183-7 - Characterization of astroglial clonal responses in experimental animal models of brain injury
Grantee:Lina Maria Delgado Garcia
Support Opportunities: Scholarships abroad - Research Internship - Doctorate