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(Reference retrieved automatically from Web of Science through information on FAPESP grant and its corresponding number as mentioned in the publication by the authors.)

Which blood cutoff value should be used for vitamin A deficiency in children aged 3-10 years? A systematic review

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Author(s):
Collese, Tatiana S. [1] ; Norde, Marina M. [2] ; Nascimento-Ferreira, V, Marcus ; Kim, Hanseul [3] ; Marchioni, Dirce M. [2] ; Carvalho, Heraclito B. [4] ; Giovannucci, Edward [3, 5]
Total Authors: 7
Affiliation:
[1] Univ Sao Paulo, Fac Med, Dept Prevent Med, Youth Child Cardiovasc Risk & Environm YCARE Res, Sao Paulo - Brazil
[2] Univ Sao Paulo, Sch Publ Hlth, Dept Nutr, Sao Paulo - Brazil
[3] Harvard Univ, Harvard TH Chan Sch Publ Hlth, Dept Epidemiol, Boston, MA 02115 - USA
[4] Nascimento-Ferreira, Marcus, V, Univ Sao Paulo, Fac Med, Dept Prevent Med, Youth Child Cardiovasc Risk & Environm YCARE Res, Sao Paulo - Brazil
[5] Harvard Univ, Harvard TH Chan Sch Publ Hlth, Dept Nutr, Boston, MA 02115 - USA
Total Affiliations: 5
Document type: Review article
Source: NUTRITION REVIEWS; v. 79, n. 7, p. 777-787, JUL 2021.
Web of Science Citations: 0
Abstract

Context: Blood cutoff values for vitamin A deficiency in children aged 3-10 years have not been addressed in the literature. Objective: To identify blood retinol concentrations for determining severe vitamin A deficiency in children aged 3-10 years. Data Sources: The MEDLINE, Web of Science, Embase, and Scopus databases were searched. Data Extraction: Two reviewers independently extracted article data and assessed quality. Data Analysis: The hierarchical summary receiver operating characteristic models were applied for the diagnostic accuracy meta-analysis. This review is registered at PROSPERO (identifier: CRD42020149367). Results: A total of 15 articles met the eligibility criteria, and 9 were included in the diagnostic accuracy meta-analysis. The summary estimates (95%CI) were: Sensitivity, 0.39 (0.20-0.62); specificity, 0.79 (0.65-0.88); positive likelihood ratio, 1.85 (1.33-2.57); and negative likelihood ratio, 0.77 (0.60-0.99). The area under the curve of the overall analysis was 0.68 (95%CI 0.63-0.72). Conclusions: Blood retinol concentrations have low diagnostic accuracy for severe vitamin A deficiency in children aged 3-10 years. Therefore, there is unclear evidence about the preferable cutoff point for determining severe vitamin A deficiency in children in this age group. (AU)

FAPESP's process: 19/13620-3 - Is there a reliable reference value for blood vitamin A in children?
Grantee:Tatiana Sadalla Collese
Support type: Scholarships abroad - Research Internship - Doctorate
FAPESP's process: 16/13922-1 - Validation of Dietary Assessment Methods in Children: SAYCARE Study
Grantee:Tatiana Sadalla Collese
Support type: Scholarships in Brazil - Doctorate
FAPESP's process: 17/00547-0 - Association of the empirical dietary inflammatory index (EDII) and single nucleotide polymorphisms in inflammatory genes with a systemic inflammatory pattern in a population-based study
Grantee:Marina Maintinguer Norde
Support type: Scholarships abroad - Research Internship - Doctorate
FAPESP's process: 16/03803-5 - Association of dietary patterns and single nucleotide plymorphisms in the genes of adiponectin, Toll like receptor-4, IL-1², IL-6, IL-10, TNF-±, CCL-2 and C reactive protein with a systemic inflammatory pattern at a population-based study - ISA-Capital
Grantee:Marina Maintinguer Norde
Support type: Scholarships in Brazil - Doctorate