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(Reference retrieved automatically from Web of Science through information on FAPESP grant and its corresponding number as mentioned in the publication by the authors.)

anostructured scaffolds containing graphene oxide for nanomedicine application

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Author(s):
Uehara, Thiers M. [1] ; Migliorini, Fernanda L. [1] ; Facure, Murilo H. M. [1, 2] ; Palma Filho, Nicolau B. [3] ; Miranda, Paulo B. [3] ; Zucolotto, Valtencir [3] ; Correa, Daniel S. [1, 2]
Total Authors: 7
Affiliation:
[1] Embrapa Instrumentacao, Nanotechnol Natl Lab Agr LNNA, BR-13560970 Sao Carlos, SP - Brazil
[2] Fed Univ Sao Carlos UFSCar, PPGQ, Dept Chem, Ctr Exact Sci & Technol, Sao Paulo - Brazil
[3] Univ Sao Paulo, Phys Inst Sao Carlos, Sao Paulo - Brazil
Total Affiliations: 3
Document type: Journal article
Source: POLYMERS FOR ADVANCED TECHNOLOGIES; v. 33, n. 2 NOV 2021.
Web of Science Citations: 0
Abstract

The use of graphene oxide (GO) has become widespread due to its advantageous properties for applications in medical devices, including cell scaffolds and sensors. Investigations on the spectroscopic and electrochemical features of nanostructured cell scaffolds may be of interest to design novel scaffolds architectures aimed at understanding their interactions with healthy and cancer cells. In this study, we investigated the interactions between liver cancer cells and two GO-containing scaffold platforms, namely: cells membrane models containing GO in the form of Langmuir-Blodgett films, and GO-modified biodegradable polycaprolactone nanofibers. Sum-frequency generation spectroscopy revealed the presence and formation of an expanded phospholipid monolayer underneath GO, while scanning electron microscopy images revealed the morphology of the cells on the different surfaces. Electrochemical impedance spectroscopy was employed to evaluate the charge transfer resistance in different nanostructured scaffolds containing liver cancer cells. The nanosystems developed here can be applied to study the interactions between cells on polymer nanofibers and Langmuir-Blodgett films modified with GO for regenerative medicine. (AU)

FAPESP's process: 17/12174-4 - Development of hybrid polymer nanofibers for agricultural applications
Grantee:Daniel Souza Corrêa
Support Opportunities: Regular Research Grants
FAPESP's process: 17/10582-8 - Production and characterization of graphene quantum dots and their application in chemical sensors
Grantee:Murilo Henrique Moreira Facure
Support Opportunities: Scholarships in Brazil - Doctorate
FAPESP's process: 18/02819-0 - Interaction of chitosans and surfactants with cell membrane models investigated by nonlinear vibrational spectroscopy
Grantee:Paulo Barbeitas Miranda
Support Opportunities: Regular Research Grants
FAPESP's process: 17/21791-7 - Development of electrochemical and colorimetric biosensors for detecting micotoxins
Grantee:Fernanda Lanzoni Migliorini
Support Opportunities: Scholarships in Brazil - Post-Doctoral
FAPESP's process: 18/22214-6 - Towards a convergence of technologies: from sensing and biosensing to information visualization and machine learning for data analysis in clinical diagnosis
Grantee:Osvaldo Novais de Oliveira Junior
Support Opportunities: Research Projects - Thematic Grants