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(Reference retrieved automatically from Web of Science through information on FAPESP grant and its corresponding number as mentioned in the publication by the authors.)

Zebrafish as a model to study inflammation: A tool for drug discovery

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Author(s):
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Belo, Marco A. A. [1, 2] ; Oliveira, Melque F. [1] ; Oliveira, Susana L. [2] ; Aracati, Mayumi F. [2] ; Rodrigues, Leticia F. [2] ; Costa, Camila C. [2] ; Conde, Gabriel [2] ; Gomes, Juliana M. M. [3] ; Prata, Mariana N. L. [4] ; Barra, Ayslan [4] ; Valverde, Thalita M. [3, 5] ; de Melo, Daniela C. [6] ; Eto, Silas F. [7] ; Fernandes, Dayanne C. [8] ; Romero, Marina G. M. C. [4] ; Correa Junior, Jose D. [3] ; Silva, Juliana O. [9] ; Barros, Andre L. B. [9] ; Perez, Andrea C. [4] ; Charlie-Silva, Ives [10]
Total Authors: 20
Affiliation:
[1] Brazil Univ UB, Lab Anim Pharmacol & Toxicol, Descalvado - Brazil
[2] Sao Paulo State Univ UNESP, Dept Prevent Vet Med, Jaboticabal - Brazil
[3] Fed Univ Minas Gerais UFMG, Dept Morphol, Belo Horizonte, MG - Brazil
[4] Fed Univ Minas Gerais UFMG, Dept Physiol & Pharmacol, Belo Horizonte, MG - Brazil
[5] Fed Univ Minas Gerais UFMG, Dept Biochem & Immunol, Belo Horizonte, MG - Brazil
[6] Fed Univ Minas Gerais UFMG, Vet Sch, Dept Zootech, Belo Horizonte, MG - Brazil
[7] Univ Fed Roraima, Postgrad Program Hlth Sci PROCISA, Boa Vista, Parana - Brazil
[8] Butantan Inst, Immunochem Lab, Sao Paulo - Brazil
[9] Fed Univ Minas Gerais UFMG, Dept Clin & Toxicol Anal, Belo Horizonte, MG - Brazil
[10] Univ Sao Paulo ICB USP, Dept Pharmacol, Prof Lineu Prestes 1524 Predio ICB 1 Butanta, BR-05508000 Sao Paulo - Brazil
Total Affiliations: 10
Document type: Journal article
Source: BIOMEDICINE & PHARMACOTHERAPY; v. 144, DEC 2021.
Web of Science Citations: 0
Abstract

This study aims to demonstrate the applicability and importance of zebrafish (Danio rerio) model to study acute and chronic inflammatory responses induced by different stimuli: carrageenan phlogogen (nonimmune); acute infection by bacteria (immune); foreign body reaction (chronic inflammation by round glass coverslip implantation); reaction induced by xenotransplantation. In addition to the advantages of presenting low breeding cost, high prolificity, transparent embryos, high number of individuals belonging to the same spawning and high genetic similarity that favor translational responses to vertebrate organisms like humans, zebrafish proved to be an excellent tool, allowing the evaluation of edema formation, accumulation of inflammatory cells in the exudate, mediators, signaling pathways, gene expression and production of specific proteins. Our studies demonstrated the versatility of fish models to investigate the inflammatory response and its pathophysiology, essential for the successful development of studies to discover innovative pharmacological strategies. (AU)

FAPESP's process: 13/25971-9 - Adaptation and development of an experimental model for studies of inflammation in Danio rerio (zebrafish)
Grantee:Melque Ferrari de Oliveira
Support Opportunities: Scholarships in Brazil - Scientific Initiation
FAPESP's process: 19/19939-1 - Effects of marine pharmaceuticals in ZFL cell line
Grantee:Ives Charlie da Silva
Support Opportunities: Scholarships in Brazil - Post-Doctoral
FAPESP's process: 18/07098-0 - Effects of marine pharmaceuticals in zebrafish and ZFL cell line - emphasis
Grantee:Leticia Veras Costa Lotufo
Support Opportunities: Regular Research Grants