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(Reference retrieved automatically from Web of Science through information on FAPESP grant and its corresponding number as mentioned in the publication by the authors.)

The effects of treadmill exercise in animal models of Parkinson's disease: A systematic review

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Ferreira, Ana Flavia F. [1] ; Binda, Karina Henrique [2, 3] ; Real, Caroline Cristiano [4, 3]
Total Authors: 3
[1] Univ Sao Paulo, Inst Biomed Sci, Dept Physiol & Biophys, Lab Cellular Neurobiol, Sao Paulo, SP - Brazil
[2] Univ Sao Paulo, Inst Biomed Sci, Dept Anat, Lab Funct Neuroanat Pain, Sao Paulo, SP - Brazil
[3] Aarhus Univ, Translat Neuropsychiat Unit TNU, Aarhus - Denmark
[4] Univ Sao Paulo, Fac Med FMUSP, Sao Paulo, SP - Brazil
Total Affiliations: 4
Document type: Review article
Source: NEUROSCIENCE AND BIOBEHAVIORAL REVIEWS; v. 131, p. 1056-1075, DEC 2021.
Web of Science Citations: 0

Parkinson's disease (PD) is a progressive disabling brain disorder. Physical exercise has been shown to alleviate the symptoms of PD and, consequently, improve patient quality of life. Exercise mechanisms involved in beneficial effects on PD have been widely investigated. This study aims to systematically review the literature on the use of treadmill exercise in PD animal models. The study was conducted according to Preferred Reporting Items for Systematic reviews and Meta-Analyses (PRISMA). Searches were conducted in MEDLINE, EMBASE, and ISI databases. In total, 78 studies were included. The dopaminergic system, behavior, neuroplasticity, neuroinflammation, mitochondria, and musculoskeletal systems were some of the outcomes evaluated by the selected studies. Based on the systematic review center for laboratory animal experimentation (SYRCLE) RoB tool, the methodologies revealed a high risk of bias and lack of information about study design, which needs attention for data reproducibility. This review can guide future studies that aim to fill existing gaps regarding the effects of treadmill exercise in PD animal models. (AU)

FAPESP's process: 18/25204-1 - Role of opioids, cannabinoids, dopamine and neuroinflammation systems on pain threshold modulated by physical exercise in a rat Parkinson Disease model using a radioactive labeled substances
Grantee:Karina Henrique Binda
Support type: Scholarships abroad - Research Internship - Master's degree
FAPESP's process: 20/02109-3 - Involvement of TRPM2 channel in neurodegeneration and microglial activation in a Parkinson's Disease model induced by 6-hydroxydopamine
Grantee:Ana Flávia Fernandes Ferreira
Support type: Scholarships in Brazil - Doctorate