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(Reference retrieved automatically from Web of Science through information on FAPESP grant and its corresponding number as mentioned in the publication by the authors.)

hotobiomodulation Improves the Inflammatory Response and Intracellular Signaling Proteins Linked to Vascular Function and Cell Survival in the Brain of Aged Rat

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Cardoso, Fabrizio dos Santos [1, 2, 3] ; Borini Mansur, Fernanda Cristina [4] ; Silva Araujo, Bruno Henrique [5] ; Gonzalez-Lima, F. [2] ; da Silva, Sergio Gomes [6, 1, 7]
Total Authors: 5
[1] Univ Mogi das Cruzes, Nucleo Pesquisas Tecnol, Av Candido Xavier Almeida & Souza 200, BR-08780911 Mogi Das Cruzes, SP - Brazil
[2] Univ Texas Austin, Dept Psychol & Inst Neurosci, Austin, TX 78712 - USA
[3] Univ Sao Paulo FMRP USP, Dept Farmacol, Fac Med Ribeirao Preto, Av Bandeirantes 3900, BR-14049900 Ribeirao Preto, SP - Brazil
[4] Hosp Israelita Albert Einstein, Sao Paulo, SP - Brazil
[5] Ctr Nacl Pesquisa Energia & Mat CNPEM, Lab Nacl Biociencias LNBio, Campinas, SP - Brazil
[6] Ctr Univ UNIFAMINAS UNIFAMINAS, Muriae, MG - Brazil
[7] Fdn Cristiano Varella FCV, Hosp Canc Muriae, Muriae, MG - Brazil
Total Affiliations: 7
Document type: Journal article
Source: Molecular Neurobiology; v. 59, n. 1 OCT 2021.
Web of Science Citations: 0

Photobiomodulation is a non-pharmacological tool widely used to reduce inflammation in many tissues. However, little is known about its effects on the inflammatory response in the aged brain. We conducted the study to examine anti-inflammatory effects of photobiomodulation in aging brains. We used aged rats (20 months old) with control (handled, laser off) or transcranial laser (660 nm wavelength, 100 mW power) treatments for 10 consecutive days and evaluated the level of inflammatory cytokines and chemokines, and the expression and activation of intracellular signaling proteins in the cerebral cortex and the hippocampus. Inflammatory analysis showed that aged rats submitted to transcranial laser treatment had increased levels of IL-1alpha and decreased levels of IL-5 in the cerebral cortex. In the hippocampus, the laser treatment increased the levels of IL-1alpha and decreased levels of IL-5, IL-18, and fractalkine. Regarding the intracellular signaling proteins, a reduction in the ERK and p38 expression and an increase in the STAT3 and ERK activation were observed in the cerebral cortex of aged rats from the laser group. In addition, the laser treatment increased the hippocampal expression of p70S6K, STAT3, and p38 of aged rats. Taken together, our data indicate that transcranial photobiomodulation can improve the inflammatory response and the activation of intracellular signaling proteins linked to vascular function and cell survival in the aged brain. (AU)

FAPESP's process: 17/16443-0 - Therapeutic potential of low-level laser in the brain of aged rats
Grantee:Fabrízio dos Santos Cardoso
Support type: Scholarships in Brazil - Doctorate