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(Reference retrieved automatically from Web of Science through information on FAPESP grant and its corresponding number as mentioned in the publication by the authors.)

Hydroalcoholic leaves extract of Vaccinium ashei Reade promotes cell cycle arrest and apoptosis on T-cell acute lymphoblastic leukemia

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Meneghetti, Dalila [1] ; Cezarotto, Verciane Schneider [1] ; do Nascimento, Natalia Paiva [2, 3] ; Migita, Natacha Azussa [2, 3] ; Correa, Juliana Ronchi [2, 3] ; Riccio, Maria Francesca [2] ; Zambaldi, Lilian Girotto [2] ; Yunes, Jose Andres [4, 2] ; Artico, Leonardo Luis [2, 3]
Total Authors: 9
[1] Univ Reg Integrada Alto Uruguai & Missoes, Frederico Westphalen, RS - Brazil
[2] Ctr Infantil Boldrini, Campinas, SP - Brazil
[3] Univ Estadual Campinas, Programa Posgrad Genet & Biol Mol, Campinas, SP - Brazil
[4] Univ Estadual Campinas, Fac Ciencias Med, Dept Genet Med, Campinas, SP - Brazil
Total Affiliations: 4
Document type: Journal article
Web of Science Citations: 0

Vaccinium ashei Reade, popularly known as Rabbiteye blueberry, has several therapeutic properties attributed to the phenolic compounds present in its leaves and fruits. Here, we sought to evaluate the effects of the hydroalcoholic extract from V. ashei leaves (Bluegem cultivar, VAB) in T-cell Acute lymphoblastic leukemia (T-ALL). The VAB extract was toxic to T-ALL cells at the similar to 60 mu g/ml concentration. T-ALL cell death occurred through apoptosis. VAB extract was found to induce micronuclei formation, p53 pathway activation, and cell cycle arrest. Those mutagenic effects were evidenced through microscopy analysis and molecular p53 pathway activation. A series of phenolic compounds were identified in VAB extract by mass spectrometry, such as vanillic acid, catechin, caffeic acid, chlorogenic acid, rutin, coumaric acid, taxifolin, quercetin and naringenin, some of which are presumed to induce DNA damage. In conclusion, the V. ashei leaves extract may have important secondary metabolites with antileukemic properties. (AU)

FAPESP's process: 19/04943-3 - IGFBP7 action on TGFb/p53 pathways and corticoids resistance in Acute Lymphoblastic Leukemia
Grantee:Leonardo Luís Artico
Support Opportunities: Scholarships in Brazil - Doctorate