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(Reference retrieved automatically from Web of Science through information on FAPESP grant and its corresponding number as mentioned in the publication by the authors.)

Imbalance between the circulating endothelium-derived apoptotic microparticles and the endothelial colony-forming units of progenitor cells in patients undergoing diagnostic coronary angiography

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Pimentel Mota, Isabela Cardoso [1] ; Souza, Livia Victorino [1] ; Parizotto, Giovanna Pachele [1] ; Thomazini, Fernanda [2] ; Henao Agudelo, Juan Sebastian [1, 3] ; Almeida, Danilo Candido [1] ; da Costa Junior, Jose Ribamar [4] ; Franco, Maria do Carmo [1, 2]
Total Authors: 8
[1] Univ Fed Sao Paulo, Sch Med, Nephrol Div, Sao Paulo - Brazil
[2] Univ Fed Sao Paulo, Sch Med, Program Translat Med, Sao Paulo - Brazil
[3] Fac Hlth Sci, Cent Unit Valle Del Cauca, Valle Del Cauca, Tulua - Colombia
[4] Dante Pazzanese Inst Cardiol, Sao Paulo - Brazil
Total Affiliations: 4
Document type: Journal article
Source: ADVANCES IN MEDICAL SCIENCES; v. 66, n. 2, p. 396-402, SEP 2021.
Web of Science Citations: 0

Purpose: The involvement of the circulating endothelium-derived microparticles (EMPs) and the endothelial progenitor cells (EPCs) has been shown in the pathogenesis of coronary artery disease (CAD). The current study aimed to explore whether the Friesinger index is associated with the levels of the apoptotic CD144+/CD31+/ annexin V+ EMPs and the number of endothelial colony-forming units of progenitor cells in patients undergoing coronary angiography. Patients and methods: Fifty-seven patients with a median age of 62 years (range: 48-84 years) were enrolled. Quantification of the apoptotic CD144+/CD31+/annexin V+ EMPs was performed by flow cytometry. The number of endothelial colony-forming units defined by CFU-Hill was assessed by cell culture. Results: There was a positive correlation between the Friesinger index and the circulating levels of the apoptotic CD144+/CD31+/annexin V+ EMPs (rho=0.817, p<0.001), whereas a negative correlation was found with the number of CFU-Hill (rho = - 0.649, p<0.001). Multivariable logistic analysis showed that the risk of having moderate/severe CAD was five times greater among male patients (OR:5.32; 95% CI: 1.19 - 16.33; p=0.038) and almost one and a half times higher among those with a higher level of apoptotic CD144+/CD31+/annexin V+ EMPs (OR:1.74; 95% CI: 1.23 - 2.28; p=0.001). Finally, the circulating levels of apoptotic EMPs labelled for CD144+/CD31+/annexin V+ presented a good discrimination of moderate/severe CAD, with an AUC of 0.85 (95% CI = 0.74 - 0.96; p< 0.001). Conclusions: Moderate or severe CAD is associated with increased levels of apoptotic EMPs and reduced EPC colony-forming capacity, increasing the occurrence of endothelial injuries. (AU)

FAPESP's process: 17/08361-3 - Evaluating recreational physical exercise, birth weight, pressure levels and components of renin-angiotensin-kallikrein-kinin system interactions in children
Grantee:Livia Victorino de Souza
Support Opportunities: Scholarships in Brazil - Post-Doctorate
FAPESP's process: 18/04013-3 - Quantification of the endothelial microparticles and analysis of the miRNA profile: evaluation of the impact on the interrelation between birth weight, blood pressure levels and endothelial function in children from 6 to 12 years of age
Grantee:Maria Do Carmo Pinho Franco
Support Opportunities: Regular Research Grants