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Hypoalgesia induced by physical exercise is dependent of PPARy receptors

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Graciana de Azambuja
Total Authors: 1
Document type: Master's Dissertation
Press: Limeira, SP.
Institution: Universidade Estadual de Campinas (UNICAMP). Faculdade de Ciências Aplicadas
Defense date:
Examining board members:
Maria Cláudia Gonçalves de Oliveira; César Renato Sartori; Igor Luchini Baptista
Advisor: Maria Cláudia Gonçalves de Oliveira

Regular exercise has been described as a good alternative for the prevention and reduction of pain, and the absence of side effects, common to available analgesics medicines is a positive point. However, exercise intensity and volume for the generation of hypoalgesia, as well as its mechanisms, are still poorly understood. Therefore, it is considered important to develop studies with protocols of physical exercise appropriate to the individual conditions that investigate the prevention and reduction of muscle pain, as well as its neurobiological mechanisms involved in exercise-induced hypoalgesia. It is known that during a painful process, the physical exercise can act in the organism through several ways. It has been the focus of studies the investigation of mechanisms involved in the transition from acute to chronic pain conditions. Besides that, activation of the PPAR? (Peroxisome Proliferator Activated Receptors Gamma) has emerged as a potential anti-inflammatory and pain reducer by drugs, and may be an important pathway of exercise-induced hypoalgesia. Thus, the objective of this study was to evaluate if the acute physical exercise were able to modulate the sensitization of central neurons, preventing the development of a state of latent hyperalgesia. Also, verify the ability of two chronic aerobic training protocols with different intensities, to induce exercise-induced hypoalgesia and, in this case, to compare its efficiencies and we evaluated whether the hypoalgesia induced by chronic physical exercise is modulated by the activation of PPAR? receptors in muscle tissue (AU)

FAPESP's process: 15/20738-0 - Exercise Induces Hypoalgesia: Effect of chronic and individualized exercise and evaluation of the involvement of PPAR-³ receptors in this process
Grantee:Graciana de Azambuja
Support Opportunities: Scholarships in Brazil - Master