Advanced search
Start date
(Reference retrieved automatically from Web of Science through information on FAPESP grant and its corresponding number as mentioned in the publication by the authors.)

Influence of Sociodemographic Characteristics and Inflammation-Related Gene Variants on the Comfort Level of Caregivers of Patients With Head and Neck Cancer

Full text
Pequeno, Daniel Paixao [1, 2] ; Viaro, Elisangela Godoi [1, 2] ; Carron, Juliana [1] ; Silva, Diego Rodrigues [3] ; Gaspar, Karla Cristina [2] ; Passos Lima, Carmen Silvia [1, 2] ; Lourenco, Gustavo Jacob [1]
Total Authors: 7
[1] Univ Estadual Campinas, Sch Med Sci, Lab Canc Genet, Rua Vital Brasil 50, BR-13083888 Campinas, SP - Brazil
[2] Univ Estadual Campinas, Sch Med Sci, Clin Oncol Serv, Campinas, SP - Brazil
[3] Univ Sao Paulo, Inst Psychol, Sao Paulo - Brazil
Total Affiliations: 3
Document type: Journal article
Web of Science Citations: 0

Background: Sociodemographic characteristics and inflammatory cytokines, such as interleukin (IL)-1 beta, IL-1 cytokine receptor type 2 (IL1R2), IL-6, and triggering receptor expressed on myeloid cells like 2 (TREML2), may influence psychological disorders, including discomfort. Single-nucleotide variants (SNVs) determine individual differences for the modulation of cytokines and indicate that genetics may also influence the comfort levels. However, the relationship between sociodemographic characteristics, holistic comfort, and the roles played by IL1B rs16944, IL1R2 rs4141134, IL6 rs1800795, and TREML2 rs3747742 SNVs on the comfort levels of family caregivers (FCGs) of head and neck cancer (HNC) patients in palliative care (PC) is unknown. Thus, its investigation consisted in the aim of the present study. Methods: A questionnaire was applied to obtain sociodemographic information on 95 FCGs. The genotypes were identified using TaqMan assays. The Holistic Comfort Questionnaire for the Caregiver, which consists of 49 questions, was used to measure comfort levels. Differences between groups were assessed by the t test and linear regression. Results: Employed FCGs (p = .04), those youngest (p = .04), smokers (p = .04), and those with IL1R2 GA or AA genotypes (p = .03) presented lower comfort regarding the overall, environmental, sociocultural, and psychospiritual domains, respectively. Conclusions: Employment status, smoking habit, young age, and SNV IL1R2 rs4141134 could influence the comfort levels of FCGs of patients with HNC in PC. (AU)

FAPESP's process: 12/17182-1 - Polymorphic genes expression analysis identified in patients with squamous cell carcinoma of base of tongue
Grantee:Gustavo Jacob Lourenço
Support Opportunities: Regular Research Grants