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(Reference retrieved automatically from Web of Science through information on FAPESP grant and its corresponding number as mentioned in the publication by the authors.)

Supercritical CO2 assisted process for the production of mixed phospholipid nanoliposomes: Unloaded and vitamin D-3-loaded vesicles

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Chaves, Matheus A. [1, 2] ; Baldino, Lucia [2] ; Pinho, Samantha C. [1] ; Reverchon, Ernesto [2]
Total Authors: 4
[1] Univ Sao Paulo, Sch Anim Sci & Food Engn, Dept Food Engn, Lab Encapsulat & Funct Foods LEnAlis, Av Duque de Caxias Norte 225, Pirassununga, SP - Brazil
[2] Univ Salerno, Dept Ind Engn, Via Giovanni Paolo II, 132, I-84084 Fisciano, SA - Italy
Total Affiliations: 2
Document type: Journal article
Source: Journal of Food Engineering; v. 316, MAR 2022.
Web of Science Citations: 0

In this study, SuperLip, an innovative technology assisted by supercritical carbon dioxide (SC-CO2), was used to produce unloaded and vitamin D-3 (VD3)-loaded nanoliposomes. Vesicles were produced using hydrogenated and nonhydrogenated phosphatidylcholine from food-grade lecithins at ratios of 30:70, 20:80 and 0:100. SuperLip was operated at 100 bar and 40 degrees C using water flow rates ranging from 2.5 to 10 mL/min. The results showed that unloaded liposomes produced by SuperLip presented a unimodal size distribution at a water flow rate of 10 mL/min, regardless of the phospholipid ratio, and mean diameters ranging from 125 to 141 nm. VD3-loaded liposomes also presented a unimodal size distribution at this water flow rate, but slightly higher diameters that ranged from 144 to 252 nm. Furthermore, the addition of 20% purified phospholipids to liposomes led to an increase in the mean size of VD3-loaded vesicles from 144 to 218 nm and an increase in the encapsulation efficiency from 66.7 to 88.9%. (AU)

FAPESP's process: 19/08345-3 - Supercritical assisted process for the coencapsulation of curcumin and vitamin D3 into liposomes
Grantee:Matheus Andrade Chaves
Support Opportunities: Scholarships abroad - Research Internship - Doctorate
FAPESP's process: 17/10954-2 - Enrichment of cornstarch with curcumin and Vitamin D3 coencapsulated in lyophilized liposomes using wet agglomeration by high shear
Grantee:Matheus Andrade Chaves
Support Opportunities: Scholarships in Brazil - Doctorate