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(Reference retrieved automatically from Web of Science through information on FAPESP grant and its corresponding number as mentioned in the publication by the authors.)

Penicillium genus as a source for anti-leukemia compounds: an overview from 1984 to 2020

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de Carvalho, Ana Calheiros [1] ; Ogawa, Jr., Claudio Yoshio [1] ; De Camillis Rodrigues, Luiza [1] ; de Medeiros, Livia Soman [1] ; Veiga, Thiago Andre Moura [1]
Total Authors: 5
[1] Univ Fed Sao Paulo, Dept Chem, Diadema - Brazil
Total Affiliations: 1
Document type: Review article
Source: Leukemia & Lymphoma; v. 62, n. 9, p. 2079-2093, JUL 29 2021.
Web of Science Citations: 0

Penicillium is a widely explored genus due to its chemical diversity and associated biological properties; in addition, it represents an important source for cytotoxic compounds with good application perspectives. Based on these aspects, in this review, Penicillium compounds that presented activity against human leukemia cell lines are being listed and discussed. For this, a careful bibliographic survey was carried out in the main electronic databases, i.e. Scopus, SciFinder, Web of Science and Pubmed. Between 1984 and 2020, thirty seven original papers were selected, when using the search terms Penicillium and leukemia. The occurrence of l-asparaginase produced by some Penicillium spp. was also highlighted since this enzyme is being employed for acute lymphoblastic leukemia and lymphosarcoma therapies. Therefore, this overview aims to demonstrate the potential of metabolites biosynthesized by Penicillium fungi which can be applied in human leukemia therapies and opportunities for designing new lead compounds. (AU)

FAPESP's process: 18/04095-0 - Analytical Approaches for Discovering Unknown Cytotoxic Compounds from Plants
Grantee:Thiago André Moura Veiga
Support type: Regular Research Grants