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(Reference retrieved automatically from SciELO through information on FAPESP grant and its corresponding number as mentioned in the publication by the authors.)

Cardiac Remodeling in Obesity-Resistance Model is not Related to Collagen I and III Protein Expression

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Author(s):
Scarlet Marques de Oliveira [1] ; Jéssica Leite Garcia [2] ; Danielle Fernandes Vileigas [3] ; Dijon Henrique Salomé de Campos [4] ; Fabiane Valentini Francisqueti-Ferron [5] ; Artur Junio Togneri Ferron [6] ; Danielle Cristina Tomaz da Silva-Bertani [7] ; Carlos Roberto Padovani [8] ; Camila Renata Corrêa [9] ; Antonio Carlos Cicogna [10]
Total Authors: 10
Affiliation:
[1] São Paulo State University. Botucatu Medical School - Brasil
[2] São Paulo State University. Botucatu Medical School - Brasil
[3] São Paulo State University. Botucatu Medical School - Brasil
[4] São Paulo State University. Botucatu Medical School - Brasil
[5] São Paulo State University. Botucatu Medical School - Brasil
[6] São Paulo State University. Botucatu Medical School - Brasil
[7] São Paulo State University. Botucatu Medical School - Brasil
[8] São Paulo State University. Institute of Bioscience - Brasil
[9] São Paulo State University. Botucatu Medical School - Brasil
[10] São Paulo State University. Botucatu Medical School - Brasil
Total Affiliations: 10
Document type: Journal article
Source: International Journal of Cardiovascular Sciences; 2021-07-26.
Abstract

Abstract Background: As some individuals present resistance to obesity development, experiments have been trying to understand their susceptibility to cardiometabolic diseases. Objetive: To evaluate if the cardiac remodeling was related to collagen protein expression change. Methods: Male Wistar rats were randomized into two experimental groups: control diet (CD, n=15) or high-fat diet (HFD, n=15) for 30 weeks. Rats fed with HFD were ranked based on their adiposity indexes and classified as obese (Ob, n = 8) or obesity-resistant (ROb, n = 6). Rats that failed to present the normal characteristic of the control group while fed with CD were excluded (Control, n = 8). Nutritional profile, comorbidities (dyslipidemia, hypertension, glucose metabolism, hyperleptinemia), cardiac remodeling, and collagen protein expression were evaluated. The groups were compared by One-Way ANOVA, together the Tukey post hoc test, with p<0.05 considered significant. Results: The Ob rats presented an increased adiposity index when compared to C and ROb. Both groups Ob and ROb presented increased low-density lipoprotein (LDL), insulin, homeostatic model assessment of insulin resistance (HOMA- IR) and systolic blood pressure (SBP), and low high-density lipoprotein (HDL) levels when compared to the control group. The levels of triglycerides, non-esterified fatty acid (NEFA), and leptin were lower in ROb as compared to Ob, but higher than the control group. The Ob and ROb groups presented cardiac remodeling, evidenced by echocardiographic and post-mortem analysis. The collagen protein expression did not differ among the groups. Conclusion: The ROb animals present cardiac remodeling that is not related to collagen type I and III protein expression change. (AU)

FAPESP's process: 12/21024-2 - Influence of obesity by saturated high-fat diet on the myocardial collagen I and III and their association with renin-angiotensin system via angiotensin II type 1 receptor
Grantee:Danielle Cristina Tomaz da Silva
Support type: Scholarships in Brazil - Doctorate
FAPESP's process: 13/23954-0 - Collagen type I and III protein expression in the myocardial of obesity resistant rats induced by saturated high-fat diet
Grantee:Scarlet Marques de Oliveira
Support type: Scholarships in Brazil - Scientific Initiation