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(Reference retrieved automatically from SciELO through information on FAPESP grant and its corresponding number as mentioned in the publication by the authors.)

Lipase-Mediated Dynamic Kinetic Resolution of 1-Phenylethanol Using Niobium Salts as Racemization Agents

Full text
Author(s):
Vanessa M. Higa [1] ; Willian S. Rocha [2] ; Mirela Inês de Sairre [3] ; Álvaro T. Omori [4]
Total Authors: 4
Affiliation:
[1] Universidade Federal do ABC. Centro de Ciências Naturais e Humanas - Brasil
[2] Universidade Federal Rural do Rio de Janeiro. Instituto de Química. Departamento de Química Orgânica - Brasil
[3] Universidade Federal do ABC. Centro de Ciências Naturais e Humanas - Brasil
[4] Universidade Federal do ABC. Centro de Ciências Naturais e Humanas - Brasil
Total Affiliations: 4
Document type: Journal article
Source: Journal of the Brazilian Chemical Society; v. 32, n. 10, p. 1956-1962, 2021-10-01.
Abstract

In this work, a racemization method of (S)-1-phenylethanol by niobium salts was developed. Among the salts available, the niobium phosphate hydrate (NbOPO4.nH2O) reduced the enantiomeric excess (ee) of the chiral alcohol from 95 to 0% after 24 h at 60 ºC in toluene. This new racemization agent was combined with a lipase (CALB) in order to achieve a chemoenzymatic dynamic kinetic resolution (DKR). Experiments demonstrated that the DKR process is feasible and the corresponding (R)-1-phenylethyl acetate was obtained with 92% conversion and 85% ee. (AU)

FAPESP's process: 17/18007-2 - EXPANDING THE USE OF CARROT BITS (Daucus carota) IN ORGANIC SYNTHESIS - APPLICATIONS IN TOTAL SYNTHESIS OF BIOACTIVE MOLECULES, NOVEL SUBSTRATES AND THE DEVELOPMENT OF A SCALE-UP METHODOLOGY
Grantee:Alvaro Takeo Omori
Support Opportunities: Regular Research Grants