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(Reference retrieved automatically from Web of Science through information on FAPESP grant and its corresponding number as mentioned in the publication by the authors.)

Molecular basis of synchronous replication of malaria parasites in the blood stage

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Dos Santos, Benedito M. [1] ; Pereira, Pedro H. S. [1] ; Garcia, Celia R. S. [1]
Total Authors: 3
[1] Univ Sao Paulo, Dept Clin & Toxicol Anal, Lab Funct Genom & Antimalarial Discovery, Sch Pharmaceut Sci, BR-05508000 Sao Paulo - Brazil
Total Affiliations: 1
Document type: Review article
Source: Current Opinion in Microbiology; v. 63, p. 210-215, OCT 2021.
Web of Science Citations: 0

The search for host factors that leads to malaria parasite synchronization has been the focus of several laboratories. The host hormone melatonin synchronizes Plasmodium falciparum in culture by increasing the number of mature parasite stages through a PLC-IP3 activation. Melatonin signaling is linked to crosstalk between Ca2+-cAMP that results in PKA activation. Two other kinases, PfPK7 and PfelK1, and the nuclear protein PfMORC that lacks melatonin sensitivity in the inducible knock-down parasites are also identified as part of the hormone-signal transduction pathways. Melatonin also modulates P. falciparum mitochondrial fission genes FIS1, DYN1, and DYN2 in a stage-specific manner. How these multiple molecular mechanisms are orchestrated to lead to parasite synchronization is a fascinating and opened biological question. (AU)

FAPESP's process: 17/08684-7 - Decoding Plasmodium signaling at molecular level as a new tool to the development of new antimalarials
Grantee:Célia Regina da Silva Garcia
Support Opportunities: Research Projects - Thematic Grants
FAPESP's process: 20/08988-9 - Evaluation of compounds with antimalarial potential and study of the signal transduction mechanism of GPCR (G-Protein Coupled Receptor) like PfSR25 in Plasmodium falciparum
Grantee:Benedito Matheus dos Santos
Support Opportunities: Scholarships in Brazil - Doctorate (Direct)