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(Reference retrieved automatically from Web of Science through information on FAPESP grant and its corresponding number as mentioned in the publication by the authors.)

In vitro antioxidant and wound healing properties of baru nut extract (Dipteryx alata Vog.) in pulmonary epithelial cells for therapeutic application in chronic pulmonary obstructive disease (COPD)

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Author(s):
Coco, Julia Cedran [1] ; Ataide, Janaina Artem [1] ; Sake, Johannes A. [2, 3] ; Tambourgi, Elias Basile [4] ; Ehrhardt, Carsten [2, 3] ; Mazzola, Priscila Gava [1]
Total Authors: 6
Affiliation:
[1] Univ Estadual Campinas, Fac Pharmaceut Sci, Campinas - Brazil
[2] Trinity Coll Dublin, Sch Pharm & Pharmaceut Sci, Dublin - Ireland
[3] Trinity Coll Dublin, Trinity Biomed Sci Inst, Dublin - Ireland
[4] Univ Estadual Campinas, Sch Chem Engn, Campinas - Brazil
Total Affiliations: 4
Document type: Journal article
Source: NATURAL PRODUCT RESEARCH; SEP 2021.
Web of Science Citations: 0
Abstract

Baru nuts (Dipteryx alata Vog.) are a native species from Brazil, rich in phenols and other antioxidants, with high socioeconomic value and possible pharmaceutical applications. Here we investigated baru nut ethanolic extract (BNEE) antioxidant and wound healing activities in human NCI-H441 and A549 lung epithelial cell lines for a possible use in conditions related to oxidative stress and wound healing impairments, such as chronic obstructive pulmonary disease (COPD). BNEE was characterised with high DPPH free radical scavenging activity and high total phenolics content, amongst them gallic acid, that was identified and quantified by HPLC. BNEE was not cytotoxic at concentrations studied, reduced the levels of reactive oxygen species before and during oxidative stress and increased wound healing in cell monolayers. These are the first steps to investigate the beneficial properties of baru in diseases related to oxidative stress and wound healing impairments such as COPD. (AU)

FAPESP's process: 18/17451-9 - Incorporation and characterization of baru nuts extract (Dipteryx alata) into liposomes
Grantee:Julia Cedran Coco
Support Opportunities: Scholarships abroad - Research Internship - Scientific Initiation
FAPESP's process: 18/06475-4 - Development of pharmaceutical formulation for burns' healing
Grantee:Janaína Artem Ataide
Support Opportunities: Scholarships in Brazil - Doctorate
FAPESP's process: 18/06043-7 - Extraction, characterization and nanoencapsulation of baru nuts (Dipteryx alata) and its application into topical formulations
Grantee:Julia Cedran Coco
Support Opportunities: Scholarships in Brazil - Scientific Initiation