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(Reference retrieved automatically from Web of Science through information on FAPESP grant and its corresponding number as mentioned in the publication by the authors.)

Effects of High-Fat and High-Fat/High-Sucrose Diet-Induced Obesity on PVAT Modulation of Vascular Function in Male and Female Mice

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Victorio, Jamaira A. [1] ; Guizoni, Daniele M. [1] ; Freitas, Israelle N. [1] ; Araujo, Thiago R. [2] ; Davel, Ana P. [1]
Total Authors: 5
[1] Univ Estadual Campinas, Inst Biol, Dept Struct & Funct Biol, Lab Vasc Biol, Campinas - Brazil
[2] Univ Estadual Campinas, Obes & Comorbid Res Ctr OCRC, Inst Biol, Dept Struct & Funct Biol, Campinas - Brazil
Total Affiliations: 2
Document type: Journal article
Source: FRONTIERS IN PHARMACOLOGY; v. 12, SEP 10 2021.
Web of Science Citations: 1

Increased adiposity in perivascular adipose tissue (PVAT) has been related to vascular dysfunction. High-fat (HF) diet-induced obesity models are often used to analyze the translational impact of obesity, but differences in sex and Western diet type complicate comparisons between studies. The role of PVAT was investigated in small mesenteric arteries (SMAs) of male and female mice fed a HF or a HF plus high-sucrose (HF + HS) diet for 3 or 5 months and compared them to age/sex-matched mice fed a chow diet. Vascular responses of SMAs without (PVAT-) or with PVAT (PVAT+) were evaluated. HF and HF + HS diets increased body weight, adiposity, and fasting glucose and insulin levels without affecting blood pressure and circulating adiponectin levels in both sexes. HF or HF + HS diet impaired PVAT anticontractile effects in SMAs from females but not males. PVAT-mediated endothelial dysfunction in SMAs from female mice after 3 months of a HF + HS diet, whereas in males, this effect was observed only after 5 months of HF + HS diet. However, PVAT did not impact acetylcholine-induced relaxation in SMAs from both sexes fed HF diet. The findings suggest that the addition of sucrose to a HF diet accelerates PVAT dysfunction in both sexes. PVAT dysfunction in response to both diets was observed early in females compared to age-matched males suggesting a susceptibility of the female sex to PVAT-mediated vascular complications in the setting of obesity. The data illustrate the importance of the duration and composition of obesogenic diets for investigating sex-specific treatments and pharmacological targets for obesity-induced vascular complications.</p> (AU)

FAPESP's process: 18/16505-8 - Perivascular adipose tissue dysfunction and inflammation in obesity: the role of mineralocorticoid receptors
Grantee:Ana Paula Couto Davel
Support type: Regular Research Grants
FAPESP's process: 13/07607-8 - OCRC - Obesity and Comorbidities Research Center
Grantee:Licio Augusto Velloso
Support type: Research Grants - Research, Innovation and Dissemination Centers - RIDC
FAPESP's process: 18/00543-8 - The role of endothelial and macrophage mineralocorticoid receptor in inflammation response and anti-contractile function of perivascular adipose tissue in obese male and female
Grantee:Jamaira Aparecida Victorio
Support type: Scholarships in Brazil - Post-Doctorate