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(Reference retrieved automatically from Web of Science through information on FAPESP grant and its corresponding number as mentioned in the publication by the authors.)

Paramyxoviruses from neotropical bats suggest a novel genus and nephrotropism

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de Souza, William Marciel [1, 2, 3] ; Fumagalli, Marcilio Jorge [1] ; Carrera, Jean Paul [4, 5] ; de Araujo, Jansen [6] ; Cardoso, Jedson Ferreira [7] ; de Carvalho, Cristiano [8] ; Durigon, Edison Luiz [6] ; Queiroz, Luzia Helena [8] ; Faria, Nuno Rodrigues [4, 9] ; Murcia, Pablo R. [10] ; Figueiredo, Luiz Tadeu Moraes [1]
Total Authors: 11
[1] Univ Sao Paulo, Virol Res Ctr, Ribeirao Preto Med Sch, Ribeirao Preto, SP - Brazil
[2] Univ Texas Med Branch, World Reference Ctr Emerging Viruses & Arboviruse, Galveston, TX 77555 - USA
[3] Univ Texas Med Branch, Dept Microbiol & Immunol, 301 Univ Blvd, Galveston, TX 77555 - USA
[4] Univ Oxford, Dept Zool, Oxford - England
[5] Gorgas Mem Inst Hlth Studies, Dept Res Virol & Biotechnol, Panama City - Panama
[6] Univ Sao Paulo, Inst Biomed Sci, Sao Paulo, SP - Brazil
[7] Minist Hlth, Evandro Chagas Inst, Ananindeua, Para - Brazil
[8] Sao Paulo State Univ, Fac Vet Med, Aracatuba, SP - Brazil
[9] Imperial Coll London, Dept Infect Dis Epidemiol, London - England
[10] MRC Univ Glasgow, Ctr Virus Res, Glasgow, Lanark - Scotland
Total Affiliations: 10
Document type: Journal article
Web of Science Citations: 0

Paramyxoviruses have a broad host range and geographic distribution, including human pathogens transmitted by bats, such as Nipah and Hendra viruses. In this study, we combined high-throughput sequencing and molecular approaches to investigate the presence of paramyxoviruses in neotropical bats (Microchiroptera suborder) in Brazil. We discovered and characterized three novel paramyxoviruses in the kidney tissues of apparently healthy common vampire bats (D. rotundus) and Seba's short-tailed bats (C. perspicillata), which we tentatively named Kanhg acute accent ag virus (KANV), Boe virus (BOEV), and Guat acute accent o virus (GUATV). In this study, we classified these viruses as putative species into the Macroje circumflex accent virus genus, a newly proposed genus of the Orthoparamyxovirinae subfamily. Using RT-PCR, we detected these viruses in 20.9% (9 out of 43) of bats tested, and viral RNA was detected exclusively in kidney tissues. Attempts to isolate infectious virus were successful for KANV and GUATV. Our results expand the viral diversity, host range, and geographical distribution of the paramyxoviruses. (AU)

FAPESP's process: 15/05778-5 - Bioinformatics analysis of data of viral metagenomic of animals from Brazil and Antarctica
Grantee:William Marciel de Souza
Support type: Scholarships abroad - Research Internship - Doctorate
FAPESP's process: 19/24251-9 - Multi-omic approaches for the study of Chikungunya disease
Grantee:William Marciel de Souza
Support type: Scholarships abroad - Research Internship - Post-doctor
FAPESP's process: 13/14929-1 - Detection of arbovirus and other RNA viruses by real time RT-PCR and study of the viroma
Grantee:Luiz Tadeu Moraes Figueiredo
Support type: Regular Research Grants
FAPESP's process: 18/09383-3 - Study about Flavivirus epitopes with medical importance in Brazil and its antibodies
Grantee:Marcilio Jorge Fumagalli
Support type: Scholarships in Brazil - Doctorate
FAPESP's process: 17/13981-0 - Characterization, genomics and diagnostic of viruses with importance for public health in Brazil by high throughput sequencing
Grantee:William Marciel de Souza
Support type: Scholarships in Brazil - Post-Doctorate
FAPESP's process: 18/14389-0 - Brazil-UK Centre for Arbovirus Discovery, Diagnosis, Genomics and Epidemiology (CADDE)
Grantee:Ester Cerdeira Sabino
Support type: Research Projects - Thematic Grants