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(Reference retrieved automatically from Web of Science through information on FAPESP grant and its corresponding number as mentioned in the publication by the authors.)

Near-Infrared Photoactive Theragnostic Gold Nanoflowers for Photoacoustic Imaging and Hyperthermia

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Santos, Olavo [1] ; Cancino-Bernardi, Juliana [1] ; Pincela Lins, Paula Maria [1] ; Sampaio, Diego [1, 2] ; Pavan, Theo [2] ; Zucolotto, Valtencir [1]
Total Authors: 6
[1] Univ Sao Paulo, Phys Inst Sao Carlos, Nanomed & Nanotoxicol Grp, BR-13566590 Sao Paulo - Brazil
[2] Univ Sao Paulo, Fac Philosophy Sci & Letters Ribeirao Preto, Phys Dept, Innovat Grp Med Instrumentat & Ultrasound GIIMUS, BR-05508220 Sao Paulo - Brazil
Total Affiliations: 2
Document type: Journal article
Source: ACS APPLIED BIO MATERIALS; v. 4, n. 9, p. 6780-6790, SEP 20 2021.
Web of Science Citations: 2

Branched anisotropic gold nanostructures present distinguished performance acting both as contrast agents for photoacoustic imaging and as active agents for photothermal therapies. Despite advances in their fabrication methods, the synthesis of such gold nanomaterials in a simple and reproducible way is still a challenge. In this paper, we report the development of branched anisotropic gold nanopartides, the so-called gold nanoflowers (AuNFs), as near-infrared active theragnostic materials for cancer therapy and diagnosis. In situ chemical synthesis of the AuNFs was optimized to obtain monodisperse nanoflowers with controllable size and optical properties. Upon varying the temperature and gold ion concentrations, it was possible to tune the optical activity of the nanoparticles from 590 to 960 nm. The AuNFs exhibited good stability in the cell culture medium, and under laser irradiation. Photoacoustic imaging revealed that the NFs could be imaged in phantom systems even at low concentrations. In vitro tests revealed that the nanoflowers were effective in the photothermal therapy of a rat hepatocarcinoma (HTC) cell lineage. In addition, no toxicity was observed to mouse fibroblast (FC3H) cells incubated with the AuNFs. Our results reveal a simple method to synthesize branched anisotropic gold nanostructures, which is a promising platform for photothermal and photoacoustic therapies. (AU)

FAPESP's process: 12/03570-0 - Nanomaterials applied to nanomedicine: development of membrane models and in vitro studies for evaluation the toxicity.
Grantee:Juliana Cancino Bernardi
Support Opportunities: Scholarships in Brazil - Post-Doctoral
FAPESP's process: 16/14303-3 - The Fifth International Conference NANOSAFE 2016
Grantee:Juliana Cancino Bernardi
Support Opportunities: Research Grants - Meeting - Abroad
FAPESP's process: 12/15630-7 - Isolation of cell membranes for use in membrane models studies of nanotoxicology
Grantee:Paula Maria Pincela Lins
Support Opportunities: Scholarships in Brazil - Scientific Initiation
FAPESP's process: 13/18854-6 - Photoacoustic and ultrasound imaging applied to tissue characterization
Grantee:Theo Zeferino Pavan
Support Opportunities: Research Grants - Young Investigators Grants