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(Reference retrieved automatically from Web of Science through information on FAPESP grant and its corresponding number as mentioned in the publication by the authors.)

Anesthesia can alter the levels of corticosterone and the phosphorylation of signaling molecules

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Pereira, Gabriela Cruz [1] ; Neto, Marcos Monico [2] ; Moreira Antunes, Hanna Karen [2] ; Lee, Kil Sun [1] ; Mello da Luz, Marcio Henrique [1]
Total Authors: 5
[1] Univ Fed Sao Paulo, Dept Biochem, Rua Pedro de Toledo 669, 8 Andar, Sao Paulo, SP - Brazil
[2] Univ Fed Sao Paulo, Dept Psychobiol, Sao Paulo, SP - Brazil
Total Affiliations: 2
Document type: Journal article
Source: BMC RESEARCH NOTES; v. 14, n. 1 SEP 19 2021.
Web of Science Citations: 0

Objective Neuroscience research using laboratory animals has increased over the years for a number of reasons. Some of these studies require the use of anesthetics for surgical procedures. However, the use of anesthetics promotes several physiological changes that may interfere with experimental results. Although the anesthetics and methods of delivery used to vary, one of the most common is ketamine associated with another compound such as xylazine. We aimed to evaluate the effect of ketamine and xylazine (KX) on corticosterone levels and on the degree of phosphorylation of p44/42 (ERK1/2), Src kinases and calcium/calmodulin-dependent kinase II (CAMKII). We also compared the effects of KX on sleep deprivation, which is known to affect the hormonal profile including corticosterone. Results We found that the use of KX can increase corticosterone levels and alter the degree of phosphorylation of signaling proteins. (AU)

FAPESP's process: 17/10404-2 - Evaluation of sleep deprivation effects on function and metabolism of amyloid-beta peptides
Grantee:Márcio Henrique Mello da Luz
Support Opportunities: Scholarships in Brazil - Doctorate
FAPESP's process: 13/00152-5 - Effect of resistance exercise in cardiac and skeletal muscle of Wistar rats submitted to paradoxical sleep deprivation
Grantee:Hanna Karen Moreira Antunes
Support Opportunities: Regular Research Grants
FAPESP's process: 11/15962-7 - Effects of resistance exercise on trophic and atrophic patways in skeletal muscle of rats with paradoxal sleep deprivation
Grantee:Marcos Mônico Neto
Support Opportunities: Scholarships in Brazil - Master
FAPESP's process: 16/04297-6 - Impacts of nutrition and sleep on expression, solubility and functions of neural proteins.
Grantee:Kil Sun Lee
Support Opportunities: Regular Research Grants