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(Reference retrieved automatically from Web of Science through information on FAPESP grant and its corresponding number as mentioned in the publication by the authors.)

Cis-trimethoxystilbene, exhibits higher genotoxic and antiproliferative effects than its isomer trans-trimethoxystilbene in MCF-7 and MCF-10A cell lines

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Goncalves, Natalia Dos Santos [1] ; Silva Pereira de Mello, Tamires Maria [1] ; Mizuno, Cassia Suemi [2] ; Haider, Saqlain [3] ; Dos Santos, Raquel Alves [1]
Total Authors: 5
[1] Univ Franca, Lab Genet & Biol Mol, Av Dr Armando Salles de Oliveira 201, BR-14404600 Franca, SP - Brazil
[2] Univ New England, Westbrook Coll Hlth Profess, Sch Pharm, Dept Pharmaceut & Social Adm Sci, Portland, ME - USA
[3] Univ Mississippi, Sch Pharm, Natl Ctr Nat Prod Res, University, MS 38677 - USA
Total Affiliations: 3
Document type: Journal article
Source: GENETICS AND MOLECULAR BIOLOGY; v. 44, n. 3 2021.
Web of Science Citations: 0

Abstract Stilbenes are a class of natural compounds with a wide variety of biological effects, such as antitumor activity. The best-known stilbene is resveratrol, whose clinical application is limited due to its low bioavailability. Methoxylated derivatives of this stilbene, including cis-trimethoxystilbene (cis-TMS) and trans-trimethoxystilbene (trans-TMS) have demonstrated more pronounced cytotoxic and anti-proliferative effects than resveratrol. Thus, the objective of this study is to evaluate and compare the cytotoxicity and antiproliferative effects of cis- and trans-TMS in MCF-7 and its normal counterpart MCF-10A. Both compounds were cytotoxic, genotoxic, and induced G2-M accumulation and cell death in the two cell lines. These results suggested that the genotoxicity of cis- and trans-TMS is involved in the reduction of cellular proliferation of MCF-7 and MCF-10A cells, but notably, such antiproliferative effects are more pronounced for cis- than trans-TMS. (AU)

FAPESP's process: 18/16461-0 - Effects of cis-trimethoxystilbene treatment after TP53 silencing by siRNA in the tumoral cell lines MCF-7 and MDA-MB-231: a cellular and molecular approach
Grantee:Raquel Alves dos Santos
Support type: Regular Research Grants
FAPESP's process: 14/12465-0 - Assessment of DNA damage response pathways modulated by structuraly-modified stilbenes
Grantee:Raquel Alves dos Santos
Support type: Regular Research Grants