Advanced search
Start date
(Reference retrieved automatically from Web of Science through information on FAPESP grant and its corresponding number as mentioned in the publication by the authors.)

Prenatal exposure to a mixture of different phthalates increases the risk of mammary carcinogenesis in F1 female offspring

Full text
de Freitas, Thiago [1] ; Zapaterini, Joyce R. [1, 2] ; Moreira, Cristiane M. [1] ; de Aquino, Ariana M. [1] ; Alonso-Costa, Luiz G. [1] ; Bidinotto, Lucas T. [3, 4, 2] ; Kass, Laura [5] ; Flaws, Jodi A. [6] ; Scarano, Wellerson R. [1] ; Barbisan, Luis F. [1]
Total Authors: 10
[1] Sao Paulo State Univ, Inst Biosci, Dept Struct & Funct Biol, UNESP, Botucatu, SP - Brazil
[2] Sao Paulo State Univ, UNESP, Sch Med, Dept Pathol, Sao Paulo, SP - Brazil
[3] Barretos Canc Hosp, Mol Oncol Res Ctr, Barretos, SP - Brazil
[4] Barretos Sch Hlth Sci, Dr Paulo Prata FACISB, Barretos, SP - Brazil
[5] UNL CONICET, Inst Salud & Ambiente Litoral ISAL, Fac Bioquim & Ciencias Biol, Ciudad Univ UNL, Santa Fe - Argentina
[6] Univ Illinois, Dept Comparat Biosci, Champaign, IL - USA
Total Affiliations: 6
Document type: Journal article
Source: Food and Chemical Toxicology; v. 156, OCT 2021.
Web of Science Citations: 0

Phthalates metabolites have been detected in the urine of pregnant and breastfeeding women. Thus, this study evaluated the adverse effects of maternal exposure to a mixture of six phthalates (Pth mix) on the mammary gland development and carcinogenesis in F1 female offspring. Pregnant female Sprague-Dawley rats were exposed daily to vehicle or Pth mix (35.22% diethyl-phthalate, 21.03% di-(2-ethylhexyl)-phthalate, 14.91% dibutyl-phthalate, 15.10% diisononyl-phthalate, 8.61% diisobutyl-phthalate, and 5.13% benzylbutyl-phthalate) by gavage at 20 mu g/kg, 200 mu g/kg or 200 mg/kg during gestational day 10 (GD 10) to postnatal day 21 (PND 21). After weaning (PND 22), some female offspring were euthanized for mammary gland analyses while other females received a single dose of N-methyl-N-nitrosourea (MNU, 50 mg/kg) or vehicle and then tumor incidence and multiplicity were recorded until PND 180. Maternal Pth mix exposure increased the number of Ki-67 and progesterone receptor-positive epithelial cells in the mammary gland from Pth mix 200 at mu g/kg and 200 mg/kg groups. In addition, tumor incidence and mean number were higher only in Pth mix at 200 mg/kg when compared to the vehicle-treated group, and percentage of tumor-free animals was lower in Pth mix at 200 mu g/kg and 200 mg/kg groups. The findings indicate that perinatal Pth mixture exposure increased susceptibility to MNU-induced mammary carcinogenesis in adult F1 female offspring. (AU)

FAPESP's process: 17/08306-2 - Oncotoxicological programming by the material exposure to the mixture of different fatalatos: multigenerational effect on prostate of rats and gene and epigenetic aspects related to prostate adenocarcinoma
Grantee:Wellerson Rodrigo Scarano
Support Opportunities: Regular Research Grants
FAPESP's process: 18/50002-3 - A collaborative study between Brazilian and US scientists: the effects of environmental chemical exposures on reproduction
Grantee:Wellerson Rodrigo Scarano
Support Opportunities: Regular Research Grants